Effects of Polyphenols on Muscle Recovery Following Downhill Jogging

Not Applicable

Not yet recruiting

• Conditions: Muscle Recovery

• Registration Number: NCT07113405
• Lead Sponsor: University of Fribourg

Brief Summary

In this research project, we want to investigate whether the combined intake of proteins and polyphenols promotes faster muscle regeneration than the sole intake of proteins or a placebo product. In the study, you will be randomly assigned to one of 3 groups. Neither the research management nor you will know which group you are assigned to. The study lasts 5 days for you as a participant. During these 5 days you will have to attend a total of 5 appointments in our laboratory. The groups differ only in the intake of the regeneration product, otherwise all measurements and appointments are identical. You will jog downhill for 30 minutes on the first day in order to strain your muscles. In order to be able to draw conclusions about the regeneration of your muscles, we will carry out the following measurements on all 5 days: Blood sampling at the fingertip, ultrasound of the thigh muscle, pain tolerance of the thigh muscle, strength tests of the thigh muscle, muscle function of the thigh muscle and jumping performance.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-07-25
• Status Verified: 2025-08
• Study First Submitted QC: 2025-08-07
• Last Update Submitted: 2025-08-07
• Study First Posted: 2025-08-08
• Last Update Posted: 2025-08-08
• Study Start: 2025-10-01
• Primary Completion: 2026-12-30
• Study Completion: 2026-12-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Signed written informed consent
• Aged between 18-40 years
• Healthy subjects

Exclusion Criteria

• Any type of food allergy (e.g. nuts)
• Health-related problems according to the "Physical Activity Readiness Questionnaire (PAR-Q)
• Current injury of the lower extremities
• Serious clinical back pain or current back injuries
• Orthopedic disorders
• Cardiovascular diseases
• Current Intake of blood-thinning medication
• Current Intake of anti-inflammatory medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in maximum knee extension force immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.	5 days	The maximal force is measured in Nm while the participant is seated on an isokinetic device.
Change in jump performance immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.	5 days	The jump performance is measured in cm while the participant are performing counter movement jumps.
Change in perceived pain immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.	5 days	Perceived pain is measured in Pa while the participant is seated on the isokinetic device. The measurement point is on vastus medialis muscle.
Change in muscle thickness immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.	5 days	Muscle thickness is measured with b-mode ultrasound in mm while the participant is sitting on the isokinetic device. The measurement point is on the vastus medialis muscle.
Change in creatine kinase levels immediately after exercise-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.	5 days	Creatine kinase is measured in U/L and determined using a capillary finger blood sample of 0.25 ml.

Trial Locations

Locations (1)

University of Fribourg; 🇨🇭 Fribourg, Switzerland