ATURAL KILLER CELL PHENOTYPE IN UNEXPLAINED RECURRENT MISCARRIAGES

Completed

• Conditions: Miscarriage; 10000211; 10021460

• Registration Number: NL-OMON48099
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 126

Inclusion Criteria

We will include non-pregnant women between the age of 18 and 36.
Group 1: *cases*
Recurrent (>2) unexplained miscarriages, defined by normal parental karyotype,
no maternal thrombophilia and no uterine abnormality.
Group 2: *controls*
Previous uncomplicated pregnancy, defined by healthy live birth after 37 weeks
of gestation without major obstetric complications.

Exclusion Criteria

- Current or recent (<3 months ago) pregnancy
- Current or recent (<2 weeks) symptomatic genital infection such as chlamydia,
gonorrea or
pelvic inflammatory disease
- Younger than 18 or older than 36 years
- Unable to give consent in Dutch

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Percentage of NK cells with an activating phenotype in peripheral blood. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Percentage of NK cells with an activating phenotype in menstrual blood<br /><br>- VO2 max: measured in millilitres per kilogramme of body weight per minute<br /><br>- Lifestyle questionnaire: Simple Lifestyle Indicator Questionnaire (SLIQ) score<br /><br>- Total body water: fat free mass in kilogramme of body weight</p><br>