The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels

Not Applicable

Withdrawn

• Conditions: Ischaemia-reperfusion (IR) Injury
• Interventions: Drug: C-type natriuretic peptide (CNP); Drug: Saline; Drug: Acetylcholine

• Registration Number: NCT01075776
• Lead Sponsor: Queen Mary University of London

Brief Summary

To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-02-23
• Study First Submitted QC: 2010-02-24
• Study First Posted: 2010-02-25
• Study Start: 2020-01
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-03
• Last Update Posted: 2020-05-05
• Primary Completion: 2022-01
• Study Completion: 2023-01

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Healthy human volunteers on no systemic medication, excepting the oral contraceptive pill

Exclusion Criteria

• History of medical illness
• Unwillingness to sign consent form
• Use of non-OCP medications
• Hypertension on examination of the blood pressure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
CNP	C-type natriuretic peptide (CNP)	Infusion of CNP prior to IR injury
Saline	Saline	Effect of saline infusion prior to IR injury
CNP	Acetylcholine	Infusion of CNP prior to IR injury
Saline	Acetylcholine	Effect of saline infusion prior to IR injury

Primary Outcome Measures

Name	Time	Method
Change in area under curve dose-response to acetylcholine after IR injury	2h

Trial Locations

Locations (1)

Queen Mary University London; 🇬🇧 London, United Kingdom