A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Don't Have a Response to Anti-TNF-α Therapy (SCRIPT)
- Conditions
- Rheumatoid Arthritis
- Interventions
- Registration Number
- NCT00476996
- Lead Sponsor
- Genentech, Inc.
- Brief Summary
This study will evaluate the efficacy and safety of ocrelizumab, compared with placebo, in patients with active rheumatoid arthritis who have an inadequate response to at least one anti-TNF-alpha therapy. Patients will be randomized to receive placebo, 200mg of intravenous ocrelizumab, or 500mg of i.v. ocrelizumab on days 1 and 15. A repeat course of i.v. treatment will be administered at weeks 24 and 26. All patients will receive stable doses of either concomitant methotrexate (7.5-25mg/week) or leflunomide (10-20mg po daily) and may receive additional DMARDs. The treatment period is planned for 48 weeks (until primary analysis) and then participants will enter the open label phase until the drug is commercialized. Target sample size is 1000.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 836
- Adult patients, ≥ 18 years of age
- Rheumatoid arthritis for at least 3 months
- Inadequate response to previous or current treatment with at least one anti-TNF-alpha agent
- Receiving either leflunomide or methotrexate for ≥ 12 weeks, with a stable dose for the last 4 weeks
- Swollen joint count (SJC) ≥ 4 (66 joint count) and tender joint count (TJC) ≥ 4 (68 joint count) at screening and baseline.
- CRP ≥ 0.6 mg/dL using a high-sensitivity assay.
- Positive rheumatoid factor or positive anti-CCP antibody or both.
- Rheumatic autoimmune disease or inflammatory joint disease, other than RA
- Any surgical procedure in past 12 weeks,or planned within 48 weeks of baseline
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ocrelizumab 500 mg x 2 IV + Non-Biologic DMARD Therapy Leflunomide Participants will receive 2 IV infusions of 500 mg of ocrelizumab, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Ocrelizumab 500 mg x 2 IV + Non-Biologic DMARD Therapy Ocrelizumab Participants will receive 2 IV infusions of 500 mg of ocrelizumab, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Ocrelizumab 500 mg x 2 IV + Non-Biologic DMARD Therapy Methotrexate Participants will receive 2 IV infusions of 500 mg of ocrelizumab, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Placebo x 2 IV + Non-Biologic DMARD Therapy Placebo Participants will receive ocrelizumab matching placebo IV in two infusions, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Ocrelizumab 200 mg x 2 IV + Non-Biologic DMARD Therapy Ocrelizumab Participants will receive 2 intravenous (IV) infusions of 200 milligram (mg) of ocrelizumab, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Placebo x 2 IV + Non-Biologic DMARD Therapy Leflunomide Participants will receive ocrelizumab matching placebo IV in two infusions, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Ocrelizumab 200 mg x 2 IV + Non-Biologic DMARD Therapy Leflunomide Participants will receive 2 intravenous (IV) infusions of 200 milligram (mg) of ocrelizumab, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Ocrelizumab 200 mg x 2 IV + Non-Biologic DMARD Therapy Methotrexate Participants will receive 2 intravenous (IV) infusions of 200 milligram (mg) of ocrelizumab, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD Placebo x 2 IV + Non-Biologic DMARD Therapy Methotrexate Participants will receive ocrelizumab matching placebo IV in two infusions, separated by 14 days (Day 1 and Day 15) in combination with any non-biologic DMARD
- Primary Outcome Measures
Name Time Method Percentage of Participants With American College of Rheumatology 20 (ACR20) Responses Weeks 24 and 48 ACR20 response: greater than or equal to (≥) 20% improvement in tender or swollen joint counts and 20% improvement in 3 of the following 5 criteria: 1) Physician's global assessment of disease activity, 2) participant assessment of disease activity, 3) Patient Assessment of Pain (visual analog scale \[VAS\]), 4) participant assessment of functional disability via a Health Assessment Questionnaire (HAQ), and 5) erythrocyte sedimentation rate (ESR) at each visit.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With EULAR Response Rates of Good/ Moderate Weeks 24 and 48 The EULAR response rate was based on the assessment of disease activity using the DAS28. The EULAR response criteria included not only change in disease activity but current disease activity. To be classified as responders, participants had to have a significant change in DAS28 and a low current disease activity. There were 4 categories of EULAR response rates: good, moderate, good/moderate, and none.
Percentage of Participants Achieving an ACR70 Response Weeks 24 and 48 ACR70 response is defined as a ≥ 70% improvement (reduction) compared with Baseline for both total joint count-68 joints (TJC68) and swollen joint count-66 joints (SJC66), as well as for three of the additional five ACR core set variables: physician's global assessment of disease activity (MDG), patient's global assessment of disease activity (PGA), patient's assessment of pain, HAQ-DI and CRP.
Percentage of Participants With a Major Clinical Response Week 48 Major clinical response was defined as achieving an ACR70 response and maintaining this response for a consecutive period of at least 6 months.
Percentage of Participants With a Reduction in the HAQ-DI Score Weeks 24 and 48 Health Assessment Questionnaire - Disability Index (HAQ-DI): The Stanford Health Assessment Questionnaire disability index is a patient reported questionnaire specific for RA. It consists of 20 questions referring to eight component. Reduction in the HAQ-DI score of 0.25 units from baseline to weeks 24 and 48 represented a minimal clinically relevant improvement.
Percentage of Participants Achieving Disease Activity Score (DAS28) Remission Weeks 24 and 48 The DAS28 score is a measure of the patient's disease activity calculated using the tender joint count (TJC) \[28 joints\], swollen joint count (SJC) \[28 joints\], patient's global assessment of disease activity \[visual analog scale: 0=no disease activity to 100=maximum disease activity\] and the erythrocyte sedimentation rate (ESR) for a total possible score of 0 to approximately 10. Scores below 2.6 indicate best disease control and scores above 5.1 indicate worse disease control. DAS28 Remission is defined as a DAS28 score \< 2.6.
Change in DAS28 From Baseline Weeks 24 and 48 The DAS28 score is a measure of the patient's disease activity calculated using the tender joint count (TJC) \[28 joints\], swollen joint count (SJC) \[28 joints\], patient's global assessment of disease activity \[visual analog scale: 0=no disease activity to 100=maximum disease activity\] and the erythrocyte sedimentation rate (ESR) for a total possible score of 0 to approximately 10.
Percentage of Participants Achieving an ACR50 Response Weeks 24 and 48 ACR50 response is defined as a ≥ 50% improvement (reduction) compared with baseline for both total joint count-68 joints (TJC68) and swollen joint count-66 joints (SJC66), as well as for three of the additional five ACR core set variables: physician's global assessment of disease activity (MDG), patient's global assessment of disease activity (PGA), patient's assessment of pain, Health Assessment Questionnaire with Disability Index (HAQ-DI), and C-Reactive Protein (CRP).
Trial Locations
- Locations (264)
Pinnacle Research Group; Llc, Central
🇺🇸Anniston, Alabama, United States
Center For Arthritis & Osteoporosis
🇺🇸Elizabethtown, Kentucky, United States
Arthritis Consultants
🇺🇸Saint Louis, Missouri, United States
Baton Rouge Clinic, Amc
🇺🇸Baton Rouge, Louisiana, United States
St. Mary'S Duluth Clinic Health System; Rheumatology Dept
🇺🇸Duluth, Minnesota, United States
Atlanta Center For Clinical Research.
🇺🇸Atlanta, Georgia, United States
Uni of Chicago
🇺🇸Chicago, Illinois, United States
Quad City Rheumatology, Sc
🇺🇸Moline, Illinois, United States
Physicians Group, LC DBA Rheumatology & Internal Medicine Associates
🇺🇸Saint Louis, Missouri, United States
Arthritis & Osteoporosis Center
🇺🇸Brooklyn, New York, United States
Intermountain Orthopaedics
🇺🇸Boise, Idaho, United States
St Luke's Whiteside Research
🇺🇸Duluth, Minnesota, United States
The Center of Rheumatology
🇺🇸Albany, New York, United States
Rheumatology, P.C.; Medical Arts Building
🇺🇸Kalamazoo, Michigan, United States
Carolina Bone & Joint P.A.
🇺🇸Charlotte, North Carolina, United States
Csi Research, Inc.
🇺🇸Cumming, Georgia, United States
Johns Hopkins University; Department of Rheumatology
🇺🇸Baltimore, Maryland, United States
David S Rosenberg
🇺🇸Florissant, Missouri, United States
Office of Andrew Sulich, Md
🇺🇸Saint Clair Shores, Michigan, United States
St. Paul Rheumatology
🇺🇸Eagan, Minnesota, United States
Coeur D'Alene Arthritis Clinic
🇺🇸Coeur d'Alene, Idaho, United States
Marietta Rheumatology Associates, Pc
🇺🇸Marietta, Georgia, United States
Arthritis Centers of Texas
🇺🇸Dallas, Texas, United States
Southern Tier Arthritis & Rheumatism
🇺🇸Olean, New York, United States
Fiechtner Research Inc
🇺🇸Lansing, Michigan, United States
Clayton Medical Research
🇺🇸Saint Louis, Missouri, United States
Asheville Arthritis & Osteoporosis Center, PA
🇺🇸Asheville, North Carolina, United States
Mark Fisher Md, Facr, Llc
🇺🇸Haddon Heights, New Jersey, United States
Rheumatology Associates of Long Island
🇺🇸Smithtown, New York, United States
Andrew Porges Pc
🇺🇸Roslyn, New York, United States
UZ Gent
🇧🇪Gent, Belgium
UZ Leuven Gasthuisberg
🇧🇪Leuven, Belgium
Southwest Rheumatology
🇺🇸Mesquite, Texas, United States
Hopital Lapeyronie; Immunologie Rhumatologie
🇫🇷Montpellier, France
Arthritis Care and Research Centre
🇺🇸Dallas, Texas, United States
Mac Research Inc.
🇨🇦Hamilton, Ontario, Canada
Tacoma Center For Arthritis Research
🇺🇸Tacoma, Washington, United States
Universitätsklinikum Freiburg; Medizinische UNI-Klinik; Abt. Innere Medizin - VI Rheumatologie
🇩🇪Freiburg, Germany
Vancouver Clinic; Research Dept
🇺🇸Vancouver, Washington, United States
Fachärzte für Innere Medizin - Rheumatologie - Dr. med. Ino Gao und Dr. med. Maria Anna Meier
🇩🇪Heidelberg, Germany
Sunshine Coast Rheumatology Research Unit
🇦🇺Maroochydore, Queensland, Australia
Schlosspark Klinik; Abt. Rheumatologie
🇩🇪Berlin, Germany
University Health Network; Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Sentara Medical Group
🇺🇸Norfolk, Virginia, United States
Centro de Estudos em Terapias Inovadoras - CETI
🇧🇷Curtiba, PR, Brazil
Klinik Duisburg; Klinik Für Rheumatologie
🇩🇪Duisburg, Germany
Arthritis Clinic of Northern Virginia
🇺🇸Arlington, Virginia, United States
Rheumatic Disease Center
🇺🇸Glendale, Wisconsin, United States
K-W Musculoskeletal Research
🇨🇦Kitchener, Ontario, Canada
Praxis Dr. med. Reiner Kurthen
🇩🇪Aachen, Germany
Inst. de Rehabilitacion Psicofisica; Reumathology
🇦🇷Buenos Aires, Argentina
CH Jean Rougier; Rhumato Reed Fonctionnelle
🇫🇷Cahors, France
Rheumapraxis PD Dr.med. Bernhard Heilig
🇩🇪Heidelberg, Germany
Klinikum der Universitat Munchen; Bereich Pettenkoferstr; Rheumaeinheit der medizinischen Klinik IV
🇩🇪München, Germany
Rheumapraxis an der Hase
🇩🇪Osnabrück, Germany
Az. Osp. Pisana Ospedale S. Chiara; U.O. Di Reumatologia
🇮🇹Pisa, Toscana, Italy
Hopital De Bois Guillaume; Rhumatologie
🇫🇷Bois Guillaume, France
Evangelisches Krankenhaus Hagen-Haspe Rheumaklinik
🇩🇪Hagen, Germany
Internistisches Praxiszentrum Am Krankenhaus Balserische Stiftung; Innere Medizin / Rheumatologie
🇩🇪Giessen, Germany
Hopital Cochin; Rhumatologie A
🇫🇷Paris, France
Hospital das Clinicas - UNICAMP
🇧🇷Campinas, SP, Brazil
Hospital Sierrallana; Servicio de Reumatologia
🇪🇸Torrelavega, Cantabria, Spain
Arcispedale Santa Maria Nuova; Reumatologia
🇮🇹Reggio Emilia, Emilia-Romagna, Italy
Hospital de Jerez de la Frontera; Servicio de Reumatologia
🇪🇸Jerez de La Frontera, Cadiz, Spain
Medizinische Hochschule Zentrum Innere Medizin Abt.Klinische Immunologie und Rheumatologie
🇩🇪Hannover, Germany
Debreceni Egyetem Orvos- és Egészségtudományi Centrum; Belgyógyászati Intézet, Reumatológiai Tanszék
🇭🇺Debrecen, Hungary
UNI-Klinikum Heidelberg Medizinische Klinik Innere Medizin V
🇩🇪Heidelberg, Germany
Klinik der Uni zu Köln; Klinik für Innere Medizin
🇩🇪Köln, Germany
Meir Medical Center; Heamatology Dept
🇮🇱Kfar Saba, Israel
Sasebo Chuo Hospital ; Internal Medicine
🇯🇵Nagasaki, Japan
Irccs Policlinico San Matteo; Reumatologia Adulti
🇮🇹Pavia, Lombardia, Italy
Hospital Universitari de Bellvitge; Servicio de Reumatologia
🇪🇸Barcelona, Spain
Seirei Hamamatsu General Hospital; Rheumatology
🇯🇵Shizuoka, Japan
Centro de Infusion Marbella; Consultorios Royal Center Num 214
🇵🇦Panama City, Panama
CHUV; Hôpital orthopédique, Rhumatologie
🇨🇭Lausanne, Switzerland
Hospital Clinic i Provincial; Servicio de Reumatologia
🇪🇸Barcelona, Spain
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Reumatologia
🇪🇸La Coruna, LA Coruña, Spain
Hospital General Universitario de Guadalajara; Servicio de Reumatologia
🇪🇸Guadalajara, Spain
Hospital Universitario Infanta Cristina; Servicio de Reumatologia
🇪🇸Badajoz, Spain
Complejo Asistencial Universitario de Burgos; Servicio de Reumatología
🇪🇸Burgos, Spain
Hospital Universitario 12 de Octubre; Servicio de Reumatologia
🇪🇸Madrid, Spain
Hospital Clinico Universitario de Salamanca; Servicio de Reumatologia
🇪🇸Salamanca, Spain
Hospital de Basurto; Servicio de Reumatologia
🇪🇸Bilbao, Vizcaya, Spain
Universitätsspital Zürich; Klinik für Rheumatologie
🇨🇭Zürich, Switzerland
Chang Gung Medical Foundation - Kaohsiung; Rheumatology
🇨🇳Kaohsiung, Taiwan
Seattle Rheumatology Associates
🇺🇸Seattle, Washington, United States
Iu Outpatient Clinical Research Facility
🇺🇸Indianapolis, Indiana, United States
Diagnostic Rheumatology & Research
🇺🇸Indianapolis, Indiana, United States
San Diego Arthritis Med Clnc
🇺🇸San Diego, California, United States
Deaconess Arthritis Center; Rheumatic Disease Study Group
🇺🇸Cincinnati, Ohio, United States
Uni of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
St. Alexius Medical Center; Arthritis Clinic
🇺🇸Bismarck, North Dakota, United States
Manitoba Clinic
🇨🇦Winnipeg, Manitoba, Canada
Royal Perth Hospital; Rheumatology
🇦🇺Shenton Park, Western Australia, Australia
Sourasky / Ichilov Hospital; Rheumatology
🇮🇱Tel Aviv, Israel
Univ. of Occupational and Environmental Health; Rheumatology, Clinical Immunology and Medicine
🇯🇵Fukuoka, Japan
East Bay Rheumatology
🇺🇸San Leandro, California, United States
Park Nicollet Inst. ; Rtrc
🇺🇸Minneapolis, Minnesota, United States
Texas Arthritis Research Center; Center for Arthritis & Rheumatic Diseases
🇺🇸San Antonio, Texas, United States
Uni of Utah Medical Center
🇺🇸Salt Lake City, Utah, United States
Hopital B Roger Salengro; Rhumatologie
🇫🇷Lille, France
Fondation Hopital Saint Joseph; Rhumatologie
🇫🇷Marseille, France
Hopital Cochin; Rhumatologie B
🇫🇷Paris, France
Hopital de L'Archet; Rhumatologie
🇫🇷Nice, France
Uni Hospital Linkoeping; Dept. of Rheumatology
🇸🇪Linkoeping, Sweden
Akademiska sjukhuset, Reumatologkliniken
🇸🇪Uppsala, Sweden
The Ottawa Hospital - Riverside Campus; the Arthritis Centre
🇨🇦Ottawa, Ontario, Canada
Hospital Universitario Clementino Fraga Filho - UFRJ; Reumatologia
🇧🇷Rio de Janeiro, RJ, Brazil
Uniklinik Mainz; I. Medizinische Klinik
🇩🇪Mainz, Germany
Universitätsklinikum Würzburg; Medizinische Klinik und Poliklinik II; Hämatologie / Onkologie
🇩🇪Würzburg, Germany
St. John'S Health System Inc.; St. John'S Medical Research
🇺🇸Springfield, Missouri, United States
Springfield Clinic
🇺🇸Springfield, Illinois, United States
Medical Specialists Clinical Research Center
🇺🇸Munster, Indiana, United States
Illinois Bone & Joint Inst.
🇺🇸Morton Grove, Illinois, United States
Evanston Northwestern Healthcare; Rheumatology
🇺🇸Evanston, Illinois, United States
Physician'S Clinic of Iowa
🇺🇸Cedar Rapids, Iowa, United States
Physicians East Pa
🇺🇸Greenville, North Carolina, United States
David Mandel Inc
🇺🇸Mayfield, Ohio, United States
Uni of Texas Southwestern Medical Center; Internal Medicine
🇺🇸Dallas, Texas, United States
Arthritis & Osteoporosis Associates, LLP
🇺🇸Lubbock, Texas, United States
Texas Research Center
🇺🇸Sugar Land, Texas, United States
Office of George Krick, Md
🇺🇸Tacoma, Washington, United States
Arthritis Northwest, Spokane
🇺🇸Spokane, Washington, United States
Bluegrass Comm Research, Inc.
🇺🇸Lexington, Kentucky, United States
Arthrocare, Arthritis Care and Research, P.C.
🇺🇸Mesa, Arizona, United States
Rheumatology Associates
🇺🇸Birmingham, Alabama, United States
Uni of Arizona Health Science Center; Dept of Rheumatology/Immunology
🇺🇸Tucson, Arizona, United States
CHI St. Vincent Medical Group Hot Springs
🇺🇸Hot Springs, Arkansas, United States
Little Rock Diagnostic Clinic
🇺🇸Little Rock, Arkansas, United States
Allergy & Rheumatology Centre
🇺🇸La Jolla, California, United States
Private Practice
🇺🇸Long Beach, California, United States
Uni of Southern California School of Medicine
🇺🇸Los Angeles, California, United States
Pacific Arthritis Care Center
🇺🇸Los Angeles, California, United States
Valerius Medical Group & Research Ctr of Greater Long Beach
🇺🇸Los Alamitos, California, United States
Stanford Uni Medical Center; Divison of Rheumatology
🇺🇸Palo Alto, California, United States
Ucsd, Dept of Medicine; Rheumatology
🇺🇸San Diego, California, United States
Arthritis Treatment Center of South Bay
🇺🇸Torrance, California, United States
Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs
🇺🇸Colorado Springs, Colorado, United States
Arthritis & Rheumatism; Disease Specialities
🇺🇸Aventura, Florida, United States
New England Research Associates
🇺🇸Trumbull, Connecticut, United States
Arthritis & Osteoporosis Center P.C.
🇺🇸Camden, Connecticut, United States
Rheumatolgy Consultants of Deleware
🇺🇸Lewes, Delaware, United States
Jacksonville Center For Clinical Research
🇺🇸Jacksonville, Florida, United States
Arthritis Rsrch of Florida, Inc.
🇺🇸Palm Harbor, Florida, United States
Sarasota Arthritis Center; Research Dept
🇺🇸Sarasota, Florida, United States
Center For Arthritis; Research Dept
🇺🇸South Miami, Florida, United States
Florida Medical Center
🇺🇸Zephyrhills, Florida, United States
Arthritis Associates
🇺🇸Erie, Pennsylvania, United States
Metrolina Medical Research
🇺🇸Charlotte, North Carolina, United States
University Hospitals Case Medical Center
🇺🇸Cleveland, Ohio, United States
Paramount Medical Research
🇺🇸Middleburg Heights, Ohio, United States
Health Research of Oklahoma, Llc
🇺🇸Oklahoma City, Oklahoma, United States
Oklahoma Medical Research Foundation
🇺🇸Oklahoma City, Oklahoma, United States
Oklahoma Center For Arthritis Therapy & Research
🇺🇸Tulsa, Oklahoma, United States
Healthcare Research Consultants
🇺🇸Tulsa, Oklahoma, United States
Bend Memorial Clinic
🇺🇸Bend, Oregon, United States
Pro Research
🇺🇸Eugene, Oregon, United States
Providence Arthritis Center
🇺🇸Portland, Oregon, United States
Portland Rheumatology Clinic Llc
🇺🇸Lake Oswego, Oregon, United States
East Penn Rheumatology Associates, Pc
🇺🇸Bethlehem, Pennsylvania, United States
Rheumatology Associates of NW Pa
🇺🇸Erie, Pennsylvania, United States
Arthritis Group
🇺🇸Memphis, Tennessee, United States
Advanced Rheumatology & Arthritis Research Center
🇺🇸Wexford, Pennsylvania, United States
Clinical Research Center of Reading
🇺🇸Wyomissing, Pennsylvania, United States
Palmetto Clinical Trial Services, LLC
🇺🇸Fountain Inn, South Carolina, United States
Unifour Medical Research Associates
🇺🇸Hickory Grove, South Carolina, United States
Medical Uni of South Carolina
🇺🇸North Charleston, South Carolina, United States
West Tennessee Research Institute
🇺🇸Jackson, Tennessee, United States
Spartanburg Medical Research
🇺🇸Spartanburg, South Carolina, United States
Rheumatology Consultants
🇺🇸Knoxville, Tennessee, United States
Amarillo Center For Clinical Research
🇺🇸Amarillo, Texas, United States
Arthritis Care & Diagnostic Center
🇺🇸Dallas, Texas, United States
Metroplex Clinical Research
🇺🇸Dallas, Texas, United States
Clinical Trials Northwest
🇺🇸Yakima, Washington, United States
Organizacion Medica de Investigacion
🇦🇷Buenos Aires, Argentina
Princess Alexandra Hospital; Rheumatology
🇦🇺Woolloongabba, Queensland, Australia
AZ Sint Jan
🇧🇪Brugge, Belgium
CHU Brugmann (Victor Horta)
🇧🇪Bruxelles, Belgium
CHU de Charleroi
🇧🇪Charleroi, Belgium
Centro Internacional de Pesquisa; Reumatologia
🇧🇷Goiania, GO, Brazil
Hospital Abreu Sodre - AACD;Pesquisa Clinica
🇧🇷Sao Paulo, SP, Brazil
Arthritis Research Centre
🇨🇦Vancouver, British Columbia, Canada
Wharton Medical Clinic; Burlington
🇨🇦Burlington, Ontario, Canada
Credit Valley, Rheumatology
🇨🇦Mississauga, Ontario, Canada
St. Joseph'S Health Care Centre; Rheumatology
🇨🇦London, Ontario, Canada
Revmatologicky Ustav
🇨🇿Prague, Czechia
Hopital Louis Pasteur; Service De Medecine Interne et de Rhumatologie
🇫🇷Colmar, France
CH Du Mans; Rhumatologie
🇫🇷Le Mans, France
Endokrinologikum Frankfurt; Rheumatologie & Gynäkologie
🇩🇪Frankfurt, Germany
Maxima Medisch Centrum; Rheumatology
🇳🇱Eindhoven, Netherlands
Timaru Hospital
🇳🇿Timaru, New Zealand
Hospital Univ. Central de Asturias; Servicio de Reumatologia
🇪🇸Oviedo, Asturias, Spain
Arthritis Center Palm Harbor
🇺🇸Palm Harbor, Florida, United States
Austin Rheumatology Research
🇺🇸Austin, Texas, United States
Walter F. Chase, Md, Pa
🇺🇸Austin, Texas, United States
Low Country Research Center
🇺🇸Charleston, South Carolina, United States
SW Florida Clinical Research
🇺🇸Tampa, Florida, United States
Clinsite;Research Division of Integrated Health Associates
🇺🇸Ann Arbor, Michigan, United States
University of Colorado Cancer Center
🇺🇸Aurora, Colorado, United States
Tampa General Hospital; Rheumatology Research Dept
🇺🇸Tampa, Florida, United States
Burnette & Silverfield, MDS
🇺🇸Tampa, Florida, United States
Kentuckiana Center For Better Bone & Joint Healthx
🇺🇸Louisville, Kentucky, United States
Beilinson Medical Center; Rheumatology
🇮🇱Petach Tikva, Israel
Javed Rheumatology Associates, Inc.
🇺🇸Newark, Delaware, United States
Arizona Arthritis & Rheumatology Research, Pllc
🇺🇸Mesa, Arizona, United States
Catalina Pointe Clinical Research, Inc.
🇺🇸Tucson, Arizona, United States
GHdC Site Saint-Joseph
🇧🇪Gilly (Charleroi), Belgium
Montreal Rheumatic Disease Centre
🇨🇦Montreal, Quebec, Canada
Groupe de Recherche En Rhumatologie Et Maladies Osseuses
🇨🇦Quebec City, Quebec, Canada
Hokkaido Uni Hospital; Second Department of Internal Medicine
🇯🇵Hokkaido, Japan
Tokyo Women's Medical University
🇯🇵Tokyo, Japan
Consultorio Privado Dr. Javier Orozco
🇲🇽Guadalajara, Mexico
Clinica San Felipe; Consultorio de Reumatología
🇵🇪Lima, Peru
Szpital Uniwersytecki; nr 2 im. Dr J. Biziela
🇵🇱Bydgoszcz, Poland
Nashua Rheumatology - Foundation Medical Partners
🇺🇸Nashua, New Hampshire, United States
Borgess Research Institute
🇺🇸Kalamazoo, Michigan, United States
ZNA Jan Palfijn
🇧🇪Merksem, Belgium
Institut de Rhumatologie de Montreal
🇨🇦Montreal, Quebec, Canada
North Mississippi Medical Ctr; Internal Medicine Associates
🇺🇸Tupelo, Mississippi, United States
Clinical Pharmacology Study Group
🇺🇸Worcester, Massachusetts, United States
Westroads Medical Group
🇺🇸Omaha, Nebraska, United States
Seacoast Arthritis and Osteoporosis Center
🇺🇸Dover, New Hampshire, United States
Assaf Harofe; Dept of Medicine B
🇮🇱Beer Yaakov, Israel
Seihoku Chuoh Hospital; Department Of Rheumatology
🇯🇵Aomori, Japan
Tokyo Medical & Dental University; Medicine & Rheumatology
🇯🇵Tokyo, Japan
Royal Uni Hospital; Medicine Dept
🇨🇦Saskatoon, Saskatchewan, Canada
Arthritis Rheumatic & Back Disease Associates
🇺🇸Voorhees, New Jersey, United States
Jackson Arthritis Clinic
🇺🇸Flowood, Mississippi, United States
Università Degli Studi Di Genova - Dimi; Reumatologia
🇮🇹Genova, Liguria, Italy
Orszagos Reumatologiai Es Fizioterapias Intezet
🇭🇺Budapest, Hungary
Budai Irgalmasrendi Kórház KHT. II. Reumatológia
🇭🇺Budapest, Hungary
CER Instituto Médico; REUMATOLOGÍA
🇦🇷Florencio Varela, Argentina
Hopital Maisonneuve- Rosemont; Rheumatology
🇨🇦Montreal, Quebec, Canada
Vas Megye Es Szombathely M.J.V. Markusovszky Korhaza
🇭🇺Szombathely, Hungary
Soroka Medical Center; Reumatology
🇮🇱Beer Sheva, Israel
Gundersen Clinic Ltd;Sec. Rheumatology/Dept. of Internal Med
🇺🇸Onalaska, Wisconsin, United States
Clin. de Rhumatologie
🇨🇦Trois-rivieres, Quebec, Canada
Osaka Minami Medical Center; Rheumatoid Arthritis
🇯🇵Osaka, Japan
Clinica San Jose Obregon; Rheumatology
🇲🇽Obregon, Mexico
Hospital Nacional Edgardo Rebagliati Martins; Servicio de Reumatología
🇵🇪Lima, Peru
Higashihiroshima Memorial Hospital; Rheumatology, Internal Medicine
🇯🇵Hiroshima, Japan
Matsubara Mayflower Hospital; Rheumatology
🇯🇵Hyogo, Japan
Jichi Medical School Hospital; Rheumatology and Clinical Immunology
🇯🇵Tochigi, Japan
Unidad de Reumatologia Rehabilitacion Integral; Centro Medico Del Angel
🇲🇽Mexicali, Mexico
Klinika Reumatologii I Chorób Wewn. Pum W Szczecinie; Samodzielny Publiczny Szpital Kliniczny Nr 1
🇵🇱Szczecin, Poland
Narodny Ustav Reumatickych Chorob - 34479; Rheumatology
🇸🇰Piestany, Slovakia
Bolnica dr. Petra Drzaja, Klinicni center Ljubljana; Klinicni oddelek za revmatologijo
🇸🇮Ljubljana, Slovenia
National Hospital Organization Kyushu Medical Center; Rheumatology and Internal Medicine
🇯🇵Fukuoka, Japan
Saitama Medical University Hospital ; Rheumatology and Applied Immunology
🇯🇵Saitama, Japan
Saitama Medical Center/School; Rheumatology, Clinical immunology
🇯🇵Saitama, Japan
Unidad De Enfermedades; Cronico Degenerativas, SC.
🇲🇽Mexico, Mexico
Academisch Medisch Centrum; Division of Clinical Immunology & Rheumatology
🇳🇱Amsterdam, Netherlands
Hospital Alberto Sabogal Sologuren; Remautology
🇵🇪Callao, Peru
Wojewodzki Szpital Zespolony; Oddzial Reumatologii
🇵🇱Elblag, Poland
Aair Research Center
🇺🇸Rochester, New York, United States
Stat Research, Inc
🇺🇸Dayton, Ohio, United States
The Governors of the Uni of Alberta; Heritage Medical Research Centre
🇨🇦Edmonton, Alberta, Canada
Ramesh Gupta - PP
🇺🇸Memphis, Tennessee, United States
Rheumatology Associates of North Alabama
🇺🇸Huntsville, Alabama, United States
Idaho Arthritis Center
🇺🇸Meridian, Idaho, United States
Center For Rheumatology & Bone Research
🇺🇸Wheaton, Maryland, United States
Corporacio Sanitaria Parc Tauli; Servicio de Reumatologia
🇪🇸Sabadell, Barcelona, Spain
Aamr Research Clinic
🇺🇸Amarillo, Texas, United States
Radiant Research
🇺🇸San Antonio, Texas, United States