NL-OMON26517招募中不适用
Genotype-guided strategy for antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Radboudumc
- 入组人数
- 2,276
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Age > 16 years
- •-Obtained written informed consent
- •-Indication for monotherapy clopidogrel 75mg once daily
- •-Ankle-brachial index < 0.9 and/or toe brachial index < 0.5
- •-Current or previous symptoms due to insufficient vascularization of one or two lower extremities, including intermittent claudication, pain at rest and/or gangrene (Rutherford category 1-6)
- •-Consulting a vascular surgeon for diagnosis, treatment and/or follow-up of peripheral arterial disease
排除标准
- •-known CYP2C19 genotype or metabolizer state
- •-treated with coumarins, Non-vitamin K Oral Anti-Coagulants (NOACs), unfractionated heparin (UFH), low molecular weight heparins (LMWH) or double antiplatelet therapy (DAPT) with ASA and a P2Y12 inhibitor for other indications
- •-contraindication for clopidogrel, ASA and/or rivaroxaban
- •-pregnant or breastfeeding women
- •-unable to give informed consent (including not being able to understand the Dutch language)
研究者
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