A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty

Not Applicable

Completed

Interventions: Drug: Ropivacaine combined with methylene blue for iliac fascia block

Brief Summary: Total hip arthroplasty is currently the most effective method for treating hip joint lesions and improving quality of life, but postoperative severe pain is not conducive to rapid recovery of patients. In recent years, the widespread application of ultrasound has achieved good clinical results in iliac fascia block for postoperative analgesia in THA. However, the use of high-dose local anesthetics can increase the risk of local anesthetic poisoning, and the single block analgesia time is generally less than 24 hours. Methylene blue, as a long-acting analgesic drug, can block the pain transmission of nerve fibers for a long time, achieving analgesic effects without damaging neurons. This study used ultrasound-guided ropivacaine combined with methylene blue to perform iliac fascia block on patients undergoing total hip replacement, with the aim of prolonging pain relief time, reducing complications, and promoting postoperative recovery on the basis of traditional methods.

Recruitment & Eligibility

Inclusion Criteria

Hip replacement surgery is indicated
ASA Class II - Class III
No history of analgesic or local anesthetic allergy
No history of alcohol abuse or narcotic drug abuse
Patients and their families have given informed consent and signed the informed consent form

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
0.25% ropivacaine+0.05% methylene blue 30ml for iliac fascia block	Ropivacaine combined with methylene blue for iliac fascia block	-

Primary Outcome Measures

Name	Time	Method
Visual Analogue Scale（VAS）	From enrollment to 48 hours after surgery， the VAS scores at both rest and with activity (passive straight leg raise at 45°) were recorded at the following time points: before block and at 2, 6, 12, 24, and 48 h postoperatively	Use a swimming ruler about 10 cm long, marked with 10 ticks on one side, and "0" and "10" at each end. A score of 0 indicates no pain, a score of 10 indicates the most severe pain that is unbearable, and the higher the score, the greater the degree of pain

Secondary Outcome Measures

Name	Time	Method
Hypersensitive C-reactive Protein	From enrollment to 48 hours after surgery	Hypersensitive C-reactive protein, like procalcitonin, is an inflammatory marker. Both have the same meaning and are used to reflect the postoperative analgesic effect
Procalcitonin	From enrollment to 48 hours after surgery	Procalcitonin is an inflammatory marker, which is associated with postoperative pain, the higher the degree of pain, the higher the procalcitonin value, the lower the pain level, and the lower the procalcitonin value, and the level of procalcitonin is used to reflect the postoperative analgesic effect
Mean Arterial Pressure	From entering the operating room to leaving the resuscitation room
Heart Rate	From entering the operating room to leaving the resuscitation room
Duration of Surgery	Intraoperative
Number of Postoperative Salvage Analgesia	From the end of surgery to 48 hours after surgery
Walking Distance for the First Time Getting Out of Bed	From the end of surgery to 48 hours after surgery
The Number of Activities of Getting Out of Bed 48 Hours After Surgery	From the end of surgery to 48 hours after surgery
Neutrophil Lymphocyte Ratio	From enrollment to 48 hours after surgery

Locations (1): Jiangyan District Hospital of traditional Chinese medicine attached to the Nanjing University of Chinese Medicine
🇨🇳
Taizhou, Jiang Su, China
Jiangyan District Hospital of traditional Chinese medicine attached to the Nanjing University of Chinese Medicine
🇨🇳Taizhou, Jiang Su, China