Oxygen Preconditioning Prevents Contrast-Induced Nephropathy
- Conditions
- Ischemic Heart Disease Congestive Heart Failure Chronic Kidney Disease Peripheral arterial Disease
- Registration Number
- JPRN-UMIN000007125
- Lead Sponsor
- Yokohama Medical Center (Department of Clinical Research)
- Brief Summary
The patient in the oxygen preconditioning group had significantly higher PaO2 (134.3 +- 27.7 vs. 90.1 +- 11.7 mmHg, P < 0.01) and significantly lesser incidence of CIN (0.6% vs. 6.1%, odds ratio 0.10, P = 0.01, 95% CI 0.01-0.75) comparing with those in the control group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 400
Not provided
peritoneal dialysis, hemodialysis treatment, cardiogenic shock, congestive heart failure, pregnancy, a history of severe allergies to contrast media, recent major bleeding, having a metformin within 48 hours of the study entry, chronic obstructive pulmonary disease, patient with the oxygen saturation lesser than 90 percent, acute coronary syndrome, severe infection, severe malnutrition, post-operative states, pituitary or adrenal dysfunction, paraquat intoxication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Contrast-Induced Nephropathy : defined as an increase in the serum creatinine concentration of 25 percent or 0.5 mg/dl from the baseline at maximum value obtained within 48 hours after the procedure
- Secondary Outcome Measures
Name Time Method sex, age (more than 70-year-old), hypertension, diabetes mellitus, dyslipidemia, a history of myocardial infarction, BNP(more than 100pg/ml), anemia, use of ACE inhibitors/ARBs, use of diuretics, use of statins, use of contast-medium (more than 150ml), eGFR (less than 60ml/min/1.73m2), PaO2 (more than 100 mmHg) As sub-analysis, among the patients with eGFR under 60ml/min/1.73m2 for CIN high risk group.