The effect of adding a very low dose of naloxone to remifentanil infusion on pai

Phase 2

Conditions: Patients undergoing complete hip replacement surgery.
Presence of orthopaedic joint implants
Z96.6

Registration Number: IRCT20220111053694N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 80

Inclusion Criteria

In this study, clinical trial of patients undergoing hip replacement surgery under general anesthesia
No contraindications for general anesthesia
No chronic pain
Between 18 and 65 years
With physical condition ASA I-II (scoring status Physical, American Society of Anesthesiologists)
Filled out a written informed consent form

Exclusion Criteria

Obesity (BMI = 30 kg / m2 )
Pregnancy (based on B-HCG check)
Dependence on drugs and alcohol
Use of any painkillers in the last 24 hours
Unusual bleeding
Ischemic heart disease
History of seizures
Decrease or increase in blood pressure by more than 30% of baseline
Any surgical complications such as prosthetic fractures or enlargement of the surgery due to extensive fractures of the pelvis
Postoperative exclusion criteria include reoperation
Excessive bleeding
Long-term ventilation (> 12 hours)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The patient's pain level. Timepoint: before the intervention and 4, 8, 12 and 24 hours after the intervention. Method of measurement: VAS scale (Based on this scale, a score between 1-10 is defined for the patient's pain).

Secondary Outcome Measures

Name	Time	Method
eed to be sedated. Timepoint: The need for other painkillers after surgery to reduce the patient's pain. Method of measurement: Checklist.;Time to first sedative. Timepoint: after surgery. Method of measurement: Checklist based on the patient's needs and pain.;Cumulative dose of painkiller used. Timepoint: The first 24 hours after the surgery. Method of measurement: Checklist (total dose used).