The Role of Sugammadex and Quantitative Monitoring in "Fast-Track Anesthesia" During Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Incidence of Postoperative Residual Weakness in the Recovery Room
研究概览
简要总结
The purpose of this research is to estimate the frequency of postoperative lasting muscle weakness in patients receiving Sugammadex after undergoing liver transplant surgery by using electromyographic device (EMG), such as TetraGraph.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients willing to participate and provide an informed consent.
- •Patients undergoing primary liver transplantation.
排除标准
- •Patients with unilateral disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
- •Patients with systemic neuromuscular diseases such as myasthenia gravis.
- •Patients with a known history of cerebrovascular accident (CVA).
- •Patients undergoing repeat liver transplantation or concomitant pancreas/kidney transplantation at the time of liver transplantation.
- •Patients admitted to the intensive care unit prior to liver transplantation.
结局指标
主要结局
Incidence of Postoperative Residual Weakness in the Recovery Room
时间窗: Approximately 10 minutes of surgery recovery period
Number of patients to experience postoperative residual weakness after receiving Sugammadex as standard of care for liver transplant surgery. Postoperative residual weakness is defined as train-of-four ratio (TOF) \<0.9. Train-of-four is a test used to measure the level of neuromuscular blockage through delivery of four consecutive stimuli to a nerve. Measurement of the muscle's response (number of twitches 1-4) to the stimuli indicates the degree of paralysis. This is measured by an EMG device placed on the thumb which is also part of standard of care for intraoperative assessment of muscle weakness. The ratio is calculated by comparing the amplitude of the fourth twitch to the first twitch. A TOF \<0.9 indicates residual weakness, a TOF equal to or greater than 0.9 indicates no residual weakness.
次要结局
- ICU Admission(30 days)
- Hospital Length of Stay(30 days)
- Postoperative Pulmonary Complications(30 days)
研究者
J. Ross Renew, M.D.
Principal Investigator
Mayo Clinic