fMRI of Flight of Ideas in Bipolar Disorder

Not Applicable

Completed

• Conditions: Bipolar Disorder
• Interventions: Other: Functional Magnetic Resonance Imaging

• Registration Number: NCT02794129
• Lead Sponsor: CHU de Reims

Brief Summary

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal probably result from an underlying disturbance in semantic networks dealing with semantic associations. The aim of our study will be to have a better comprehension of thought disorders in bipolar disorder by cognitive exploration of semantic processing.

Detailed Description

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. During these episodes, formal thought disorders are observed, associated to emotional perturbation, behaviour troubles and some psychotic symptoms. During mania, the type of thought disorders observed are derailment, flight of ideas, with an increase in the amount of spontaneous speech and loss of goal. These observations of the patient's speech and language behaviour probably result from an underlying disturbance in semantic networks dealing with semantic associations. These networks have been studied extensively in schizophrenia but remain unknown in bipolar disorder. In this context, the aim of our study will be to have a better comprehension of formal thought disorders in bipolar disorder by cognitive exploration of semantic activation and inhibition.

Study Timeline

• Study Start: 2013-08
• Status Verified: 2016-05
• Study First Submitted: 2016-05-30
• Study First Submitted QC: 2016-06-07
• Study First Posted: 2016-06-08
• Primary Completion: 2018-04
• Study Completion: 2018-09
• Last Update Submitted: 2019-04-08
• Last Update Posted: 2019-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Bipolar Disorder patients	Functional Magnetic Resonance Imaging	-
Healthy Controls	Functional Magnetic Resonance Imaging	-

Primary Outcome Measures

Name	Time	Method
brain activation profiles by Functional Magnetic Resonance Imaging	inclusion visit

Trial Locations

Locations (1)

Chu Reims; 🇫🇷 Reims, France