EFFECT OF DEXMEDETOMIDINE WITH BUPIVACAINE VERSUS BUPIVACAINE ALONE IN BILATERAL QUADRATUS LUMBORUM BLOCK FOR POST OPERATIVE ANALGESIA AFTER CAESAREAN DELIVERY

Phase 4

Completed

• Conditions: Pregnancy, childbirth and the puerperium,

• Registration Number: CTRI/2020/09/027583
• Lead Sponsor: Varun Karuppiah T

Brief Summary

The Quadratus Lumborum block (QLB) is an abdominal truncal block usedfor somatic analgesia of both the upper and lower abdomen. The more posterior QLBprovide superior local anaesthetic spread to the para vertebral space andsympathetic nerves in the thorocolumbar fascia. The wider spread of the localanaesthetic agents produce extensive post-operative analgesia which has beenproven in Caesarean deliveries.

The effect of Dexmedetomidine as anadjuvant with local anaesthetic has not been extensively studied in QLB,whereas the same has been shown to prolong the duration of analgesia inTransversus Abdominis Plane (TAP) block.

In this prospective, randomized study, we  aimed to comparebilateral quadratus lumborum block with dexmedetomidine and bupivacaine versusbupivacaine alone for post- operative analgesia after caesarean delivery.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-09
• Study Completion: 2021-05-31
• Last Update Posted: 2023-12-28

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

Singleton pregnancy, gestation age of at least 37 weeks, undergoing Caesarean section under spinal anesthesia of ASA grades 2.

Exclusion Criteria

• 1.Patient refusal.
• 2.Age <18 or >45 years 3.BMI >32 4.Allergy to local anesthesic agents.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to initial onset of pain (VAS 4) and time to first rescue analgesia	0 mins | 30 mins | 1 hr | 2 hrs | 4hrs | 8hrs | 12hrs | 16hrs | 20hrs | 24hrs

Secondary Outcome Measures

Name	Time	Method
Number of rescue analgesia used	24 hours

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine; 🇮🇳 Chennai, TAMIL NADU, India

Department of Anaesthesiology and Pain Medicine

🇮🇳Chennai, TAMIL NADU, India

Varun KaruppiahT

Principal investigator

9884039276

varunk1495@gmail.com