Fysiological determinants of oxygen uptake kinetics in patients with chronic heart failure

Completed

• Conditions: heart failure; left ventricular dysfunction; 10019280

• Registration Number: NL-OMON31396
• Lead Sponsor: Máxima Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 19

Inclusion Criteria

- Heart Failure, New York Heart Association (NYHA) Class II of III, > 6 months, > 3 months stable
- Ejection fraction <40%
- ischaemic cardiomyopathy or dilating cardiomyopathy

Exclusion Criteria

- Pacemaker, ICD
- Unstable AP, myocardial infarction < 3 months before inclusion
- Atrial fibrillation or flutter
- Intracardial shunts of other congenital heart disease
- COPD with FEV1/FVC < 60%
- Pulmonary hypertension
- Negative Allen test on both sides

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Correlation's between the time constants of oxygen uptake, cardiac output,<br /><br>oxygenated hemoglobin (O2Hb) and phosphocreatin (PCr) resynthesis. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Differences between the time constants of oxygen uptake, cardiac output,<br /><br>oxygenated hemoglobin (O2Hb) and phosphocreatin (PCr) resynthesis. </p><br>