Comparison of effect of two different Dexmedetomidine infusion rates on emergence agitation in paediatric surgical patients receiving general anaesthesia with volatile anaesthetic agents
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Department of Anaesthesiology
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- The study aims to provide evidence on whether a lower infusion rate (0.2 mcg/kg/hr) is as effective as a slightly higher rate (0.3 mcg/kg/hr) in preventing EA, while minimizing hemodynamic instability. The results could guide pediatric anesthesia practice by optimizing dexmedetomidine dosing protocols, improving patient safety, enhancing recovery profiles and reducing perioperative complications related to EA.
Overview
Brief Summary
This prospective randomized study aims to compare two dexmedetomidine infusion rates 0.2 and 0.3 micrograms per kilogram per hour for preventing emergence agitation in children aged two to twelve years undergoing general anesthesia One hundred patients will be divided into two equal groups and given standardized anesthesia using volatile agents Emergence agitation and pain will be assessed using clinical scales in the postoperative period The study will compare the incidence severity recovery time and adverse effects including bradycardia hypotension and desaturation to identify the optimal infusion rate that ensures effective prevention of emergence agitation with stable hemodynamic parameters
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Masking
- None
Eligibility Criteria
- Ages
- 2.00 Year(s) to 12.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •(i) Age group 2 to 12 years (ii) Both male and female patients (iii) ASA grade I to II (iv) Undergoing elective surgery in GA.
Exclusion Criteria
- •(i) Patients or Parents refusal to consent for the study (ii) Patient with Respiratory and cardiac Diseases (iii) Delayed Milestones (iv) Patient with psychiatric disease (v) ASA Grade III and above (vi) Emergency surgery under GA.
Outcomes
Primary Outcomes
The study aims to provide evidence on whether a lower infusion rate (0.2 mcg/kg/hr) is as effective as a slightly higher rate (0.3 mcg/kg/hr) in preventing EA, while minimizing hemodynamic instability. The results could guide pediatric anesthesia practice by optimizing dexmedetomidine dosing protocols, improving patient safety, enhancing recovery profiles and reducing perioperative complications related to EA.
Time Frame: Interim Assessments after every 06 months
Secondary Outcomes
- 1.Comparison of duration of recovery in each group(2. Adverse events in each group)
Investigators
Dr Harindra Kumar Goje
INHS ASVINI