Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

Not Applicable

Completed

• Conditions: Diet, Healthy; High Intensity Interval Training
• Interventions: Dietary Supplement: moderate restricted diet (1800-2000 kcal/day) for four weeks

• Registration Number: NCT04830995
• Lead Sponsor: Cairo University

Brief Summary

Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Detailed Description

This study was carried out upon twenty multigravida pregnant female between 5-6 months gestation with IR calculated by HOMA test (fasting blood glucose× fasting insulin) ÷ 22.5. Fasting blood glucose was assessed by the method approved by (7, 13) .The test materials for this method were supplied as kits by "Diamond Diagnostics," while Insulin concentrations were stated in formerly frozen and defrosted serum samples by enzyme immunoassay using the human Insulin ELISA kits.

Study Timeline

• Study Start: 2020-03-24
• Primary Completion: 2020-10-30
• Study Completion: 2020-11-01
• Study First Submitted: 2021-04-01
• Study First Submitted QC: 2021-04-01
• Study First Posted: 2021-04-05
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-18
• Last Update Posted: 2023-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• forty multigravida females.
• their age ranged between 25 to 35 years old.
• Body mass index (BMI) <30kg/ m².

Exclusion Criteria

• females with pelvic pathology as endometriosis.
• females have irregular menstrual cycles.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
diet program	moderate restricted diet (1800-2000 kcal/day) for four weeks	moderate restricted diet (1800-2000 kcal/day) for four weeks, 3 sessions weekly
high intensity interval training	moderate restricted diet (1800-2000 kcal/day) for four weeks	high intensity interval training for four weeks, 3 sessions weekly

Primary Outcome Measures

Name	Time	Method
Fasting blood glucose level	three months	Fasting blood glucose level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.

Secondary Outcome Measures

Name	Time	Method
Fasting Insulin Level	three months	Fasting blood insulin level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.

Trial Locations

Locations (1)

Ghada Elrefaye; 🇪🇬 Giza, Egypt