Evaluation of the role of trained innate immunity in the development of rheumatoid arthritis

Completed

• Conditions: artralgia; reumatoid artritis; 10003816; 10023213

• Registration Number: NL-OMON40866
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

patients with clinically suspect arthralgia and inflammation on the MRI
patients diagnosed with RA
healthy volunteers
aged >=18 years
all subjects have to give their written informed consent.

Exclusion Criteria

not fulfilling inclusioncriteria

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In case prolonged increased responsiveness of monocytes is one of the hits in<br /><br>the multiple hit process of RA we anticipate that:<br /><br>- There are differences in monocytes of RA patients and healthy controls.<br /><br>- It is an early phenomenon, so it is already present in patients with<br /><br>clinically suspect arthralgia with subclinical inflammation on the MRI.<br /><br>These hypotheses will be tested in this study.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>