NCT00630123已完成不适用
Effect of Electroconvulsive Therapy (ECT) and Transcranial Magnetic Stimulation (TMS) on Serum Levels of Brain Derived Neurotrophic Factor in Depressed Patients.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Serum levels of BDNF.
研究概览
简要总结
To investigate the change in brain derived neurotrophic factor (BDNF) between pre and post treatment for patients with depression with either ECT or TMS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •MDD or bipolar disorder;
- •current depressive episode, ham-d17>17 and ymrs<8;
- •recommended to receive ECT or TMS as part of clinical care;
- •male/female;
- •age 18-65;
- •inpatient or outpatient;
- •comorbid dysthymic disorder, gad, or social anxiety will be included;
- •able to give written consent and agree.
排除标准
- •current manic, hypomanic, or mixed episode, ymrs>7;
- •current schizophrenia, anorexia, bulimia, substance dependence (current within past 6 months excluding caffeine and nicotine);
- •TMS or ECT in the last 3 months;
- •any other primary diagnosis;
- •uncontrolled medical illness;
- •epilepsy or severe personality disorder at the discretion of the investigators;
- •3 weeks prior to first blood test, antidepressants, mood stabilizers, antipsychotics can not be added or increased;
- •pregnant women or women of childbearing potential not willing to use appropriate contraception, nursing women;
- •known intolerance or lack of response to treatment receiving as judged by the investigator;
- •medical conditions that would affect serum levels of BDNF;
- •involvement in planning and conduct of the study.
结局指标
主要结局
Serum levels of BDNF.
时间窗: pre and post treatment
次要结局
- Correlation between the change in BDNF levels and illness severity after treatment.(pre and post treatment)
研究者
Dr. Roumen Milev
Principal Investigator
Queen's University
研究点 (1)
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