DRKS00011008已完成不适用
europhysiological and morphological studies on endogenous pruritic inhibition by thermal pain (Diffuse Pruritic Inhibitory Control, DPIC) in chronic pruritus patients and healthy controls
Kompetenzzentrum chronischer Pruritus (KCP) und Klinik für Hautkrankheiten Universitätsklinikum Münster0 个研究点目标入组 200 人开始时间: 2016年9月9日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- All
入选标准
- •Patients with chronic pruritus and matched (age and gender) healthy controls
排除标准
- •- maximal pruritus intensity <3 (VAS, 0-10) in the first two minutes after cowhage or histamine application
- •- skin lesions in the testing site (e.g. erosions, infection)
- •- neurological or severe psychiatric comorbidities according to the medical history
- •- skin type = III (Fitzpatrick; Mediterranean and darker skin types are excluded due tot he lack of data in healthy controls)
- •- allergy against the study substances
- •- disease that prevents the participation in the study
- •- use of medication that influences the perception of pruritus up to1 week prior to study start (e.g. antihistamines, pregabaline/gabapentine, opioids)
- •- use of urea, polidocanol, capsaicin, topical steroids, topical keratolytica, exfoliatives, self-tanners, topical or systemic antihistamines, anticonvulsivants, sedatives up to 1 week prior to study start
- •- systemic steroids up to 2 weeks prior to study start
- •- topical or systemic immunmodulators, antidepressants, drugs against migraine up to 1 month prior to study start
- •- non steroidal or other non-opioid pain killers up to 2 days prior to study start
- •- use of cosmetics or skin care products on the study day
- •- pregnant or breastfeeding women
- •Healthy controls:
- •- pruritus
研究者
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