europhysiological and morphological studies on endogenous pruritic inhibition by thermal pain (Diffuse Pruritic Inhibitory Control, DPIC) in chronic pruritus patients and healthy controls

Kompetenzzentrum chronischer Pruritus (KCP) und Klinik für Hautkrankheiten Universitätsklinikum Münster0 sites200 target enrollmentSeptember 9, 2016

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: L29.8
Sponsor: Kompetenzzentrum chronischer Pruritus (KCP) und Klinik für Hautkrankheiten Universitätsklinikum Münster
Enrollment: 200
Status: Completed
Last Updated: last year

No summary available.

Registry

who.int

Start Date

September 9, 2016

End Date

October 15, 2020

Last Updated

last year

Study Type

Observational

Sex

All

Sponsor

Kompetenzzentrum chronischer Pruritus (KCP) und Klinik für Hautkrankheiten Universitätsklinikum Münster

•\- maximal pruritus intensity \<3 (VAS, 0\-10\) in the first two minutes after cowhage or histamine application
•\- skin lesions in the testing site (e.g. erosions, infection)
•\- neurological or severe psychiatric comorbidities according to the medical history
•\- skin type \= III (Fitzpatrick; Mediterranean and darker skin types are excluded due tot he lack of data in healthy controls)
•\- allergy against the study substances
•\- disease that prevents the participation in the study
•\- use of medication that influences the perception of pruritus up to1 week prior to study start (e.g. antihistamines, pregabaline/gabapentine, opioids)
•\- use of urea, polidocanol, capsaicin, topical steroids, topical keratolytica, exfoliatives, self\-tanners, topical or systemic antihistamines, anticonvulsivants, sedatives up to 1 week prior to study start
•\- systemic steroids up to 2 weeks prior to study start
•\- topical or systemic immunmodulators, antidepressants, drugs against migraine up to 1 month prior to study start