Effects of Chocolate on Coronary Vasomotion in Patients After Heart Transplantation
- Conditions
- Heart Transplantation
- Registration Number
- NCT00521573
- Lead Sponsor
- University of Zurich
- Brief Summary
The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
- Detailed Description
Dark chocolate contains a high amount of flavonoids. Flavonoids hold the possibilities to improve oxidative stress and hence the possibility to improve endothelium-dependent coronary vasomotion, which is a powerful surrogate for clinical prognosis. Coronary atherosclerosis is promoted by impaired endothelial function and increased platelet activation. High oxidative stress and reduced antioxidant defenses play a crucial role in the pathogenesis of atherosclerosis, in particular in transplanted hearts. The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
- Patients after heart transplantation not requiring immediate coronary intervention
- Age 20 - 80
- Written obtained informed consent
- Heart failure (acute or chronic >NYHA II)
- Ventricular tachy-arrythmias or AV-Block >I°
- Renal insufficiency (>200 μmol/l) or liver disease (ALT or AST >150 IU)
- Symptomatic hypotension, hypertension >160/100mmHg
- Known allergy to compounds dark chocolate
- Acute infectious disease
- Disease with systemic inflammation (e.g. rheumatoid arthritis, M. Crohn)
- Participation in another study within the last month
- Concomitant vitamin supplements
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method