Effect of an N/L-type Ca channel blocker on prorenin and soluble (pro)renin receptor levels in hypertensive patients: A randomized controlled trial
Not Applicable
Recruiting
- Conditions
- Essential hypertension
- Registration Number
- JPRN-UMIN000016123
- Lead Sponsor
- Tokyo Women's Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1,Patients with chronic kidney disease (CKD) stage 4 or greater 2,Patients with past histories of myocardial or cerebral infarction within the previous six months 3,Expectant mothers and lactating women 4,Patiens who have allergy to amlodipine or cilnidipine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma levels of prorenin and soluble (pro)renin receptor
- Secondary Outcome Measures
Name Time Method 1, blood pressure, pulse rate 2, renal function: urinary protein/creatinine ratio, urinary albumin/creatinine ratio, eGFR, cystatin C, pentosidine 3, renin-angiotenin system: plasma renin activity, plasma renin concentration, plasma aldosterone concentration 4, sympathetic nervous system: catecholamine 5, oxidative stress marker: urine 8-OHdG 6, vascular endothelial function: flow-mediated dilation(FMD) 7, atherosclerosis: cardio-ankle vascular index(CAVI), augmentation index(AI)