MedPath

Collecting Tumor Samples From Patients With Gynecological Tumors

Completed
Conditions
Cervical Small Cell Carcinoma
Endometrioid Stromal Sarcoma
Ovarian Serous Cystadenocarcinoma
Recurrent Cervical Carcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Ovarian Germ Cell Tumor
Recurrent Uterine Corpus Carcinoma
Recurrent Vaginal Carcinoma
Recurrent Vulvar Carcinoma
Stage I Ovarian Cancer
Interventions
Other: Laboratory Biomarker Analysis
Registration Number
NCT00897442
Lead Sponsor
Gynecologic Oncology Group
Brief Summary

This laboratory study is collecting tumor tissue and blood samples from patients with gynecologic tumors. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help in the study of cancer.

Detailed Description

PRIMARY OBJECTIVES:

I. To collect gynecologic tissue and blood from participating Gynecologic Oncology Group (GOG) institutions.

II. To provide a repository for long-term storage of gynecologic tissue and blood that will be used in studies designed to better understand the molecular biology of gynecologic tumors.

III. To make available, through the GOG Tissue Bank, tissue and blood for proposed projects conducted by GOG and non-GOG investigators.

OUTLINE:

Snap frozen tumor tissue, OCT molds of tumor tissue, formalin-preserved tumor tissue, buffy coat-prepared tumor tissue, and blood samples are collected and stored in the repository. Patient information is kept confidential, and patients are not informed of any research/test results from use of their tissues.

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
275
Inclusion Criteria
  • Any of the following:

    • Patients who have had gynecologic tissue removed during surgery to diagnosis, treat, monitor, and/or prevent primary, persistent, or recurrent gynecologic cancer of the ovary, peritoneum, fallopian tube, cervix, uterine corpus, vagina, or vulva, meeting at least one of the following criteria:

      • Group A: Women who underwent surgery, were diagnosed with a primary gynecologic malignancy of the ovary, cervix, uterine corpus, or vulva, and have primary tumor, normal tissue, and blood available for submission for this protocol

        • Patients with ovarian cancer including all stages, grades, and common epithelial cell types

          • Invasive cancers and serous and mucinous borderline tumors of low malignant potential are allowed
          • At least 1 gram of frozen primary tumor tissue must be submitted for this protocol for patients with FIGO stage III or IV epithelial ovarian cancer
        • Patients with an invasive malignancy of the cervix or uterine corpus including all stages, grades, and common cell types

        • Patients with squamous cell carcinoma of the vulva

      • Group B: Women who underwent surgery and were diagnosed with a rare gynecologic malignancy of the ovary, peritoneum, fallopian tube, cervix, uterine corpus, vagina, vulva, a gestational trophoblastic tumor, or a tumor arising in endometriosis, and have tumor tissue available for submission for this protocol

        • Patients with a rare gynecologic malignancy of the ovary including malignant germ cell tumors; sex cord-stromal tumors; malignant mixed mesodermal tumors; clear cell, mucinous, small cell, or transitional cell carcinomas; malignant Brenner tumors; or borderline tumors of low malignant potential (except serous and mucinous)
        • Patients with a rare gynecologic malignancy of the peritoneum, including primary peritoneal cancer or mesothelioma
        • Patients with carcinoma of the fallopian tube
        • Patients with a rare gynecologic malignancy of the cervix including verrucous, small cell, clear cell, serous, or adenoid cystic carcinomas; carcinoid tumors; malignant mixed mesodermal tumors; or leiomyosarcoma
        • Patients with a rare gynecologic malignancy of the uterine corpus including leiomyosarcoma; malignant mixed mesodermal tumors; endometrial stromal sarcomas; smooth muscle tumors of unknown malignant potential; or clear cell or small cell carcinomas
        • Patients with a rare gynecologic malignancy of the vagina including verrucous or clear cell carcinomas; melanoma; embryonal rhabdomyosarcoma; or endodermal sinus tumor
        • Patients with a rare gynecologic malignancy of the vulva including verrucous carcinoma; melanoma; aggressive angiomyxoma; sarcoma; malignant Paget's disease; or Bartholin gland carcinoma
        • Patients with a gestational trophoblastic tumor
        • Patients with a tumor arising in endometriosis
      • Group C: Women who underwent prophylactic oophorectomy and have at least 1 gram of ovarian tissue and blood available for submission for this protocol

      • Group D: Women who underwent surgery to monitor or treat a persistent or recurrent gynecologic malignancy of the ovary, peritoneum, fallopian tube, cervix, uterine corpus, vagina, or vulva, and have persistent or recurrent tumor, normal tissue, and blood available for submission for this protocol

  • Concurrent primary cancers are allowed

  • No benign cystic tumors of the ovary, including cystic epithelial tumors and mature cystic teratomas

  • Prior cytotoxic chemotherapy allowed

  • Prior hormonal therapy allowed

  • Prior radiotherapy allowed

  • Prior surgery allowed

  • No more than 6 weeks after prior surgery

Exclusion Criteria

Not provided

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Ancillary-Correlative (biomarker sampling and analysis)Laboratory Biomarker AnalysisSnap frozen tumor tissue, OCT molds of tumor tissue, formalin-preserved tumor tissue, buffy coat-prepared tumor tissue, and blood samples are collected and stored in the repository. Patient information is kept confidential, and patients are not informed of any research/test results from use of their tissues.
Primary Outcome Measures
NameTimeMethod
Create a repository for long-term storage of these specimensBaseline
Make available tissue and blood for proposed projectsBaseline
Collection of gynecological tumor specimens and serum from patients at GOG institutionsBaseline
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (187)

Northside Hospital

🇺🇸

Atlanta, Georgia, United States

Ohio State University Comprehensive Cancer Center

🇺🇸

Columbus, Ohio, United States

Riverside Methodist Hospital

🇺🇸

Columbus, Ohio, United States

The Union Memorial Hospital

🇺🇸

Baltimore, Maryland, United States

Fox Chase Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

Zale Lipshy University Hospital

🇺🇸

Dallas, Texas, United States

MedStar Franklin Square Medical Center/Weinberg Cancer Institute

🇺🇸

Baltimore, Maryland, United States

Temple University Hospital

🇺🇸

Philadelphia, Pennsylvania, United States

UT Southwestern/Simmons Cancer Center-Dallas

🇺🇸

Dallas, Texas, United States

Parkland Memorial Hospital

🇺🇸

Dallas, Texas, United States

Clements University Hospital

🇺🇸

Dallas, Texas, United States

UPMC-Magee Womens Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Case Western Reserve University

🇺🇸

Cleveland, Ohio, United States

Rush University Medical Center

🇺🇸

Chicago, Illinois, United States

University of Illinois

🇺🇸

Chicago, Illinois, United States

The Methodist Hospital System

🇺🇸

Houston, Texas, United States

Virginia Mason CCOP

🇺🇸

Seattle, Washington, United States

Virginia Mason Medical Center

🇺🇸

Seattle, Washington, United States

Pacific Gynecology Specialists

🇺🇸

Seattle, Washington, United States

Fred Hutchinson Cancer Research Center

🇺🇸

Seattle, Washington, United States

Seattle Cancer Care Alliance

🇺🇸

Seattle, Washington, United States

Swedish Medical Center-First Hill

🇺🇸

Seattle, Washington, United States

University of Washington Medical Center

🇺🇸

Seattle, Washington, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

🇺🇸

Miami, Florida, United States

Indiana University/Melvin and Bren Simon Cancer Center

🇺🇸

Indianapolis, Indiana, United States

Saint Vincent Hospital and Health Care Center

🇺🇸

Indianapolis, Indiana, United States

Sunrise Hospital and Medical Center

🇺🇸

Las Vegas, Nevada, United States

Women's Cancer Center of Nevada

🇺🇸

Las Vegas, Nevada, United States

University of Minnesota/Masonic Cancer Center

🇺🇸

Minneapolis, Minnesota, United States

Good Samaritan Hospital - Cincinnati

🇺🇸

Cincinnati, Ohio, United States

University of Cincinnati

🇺🇸

Cincinnati, Ohio, United States

UCSF Medical Center-Mount Zion

🇺🇸

San Francisco, California, United States

Meharry Medical College

🇺🇸

Nashville, Tennessee, United States

Vanderbilt University/Ingram Cancer Center

🇺🇸

Nashville, Tennessee, United States

Wayne State University/Karmanos Cancer Institute

🇺🇸

Detroit, Michigan, United States

University of Oklahoma Health Sciences Center

🇺🇸

Oklahoma City, Oklahoma, United States

East Carolina University

🇺🇸

Greenville, North Carolina, United States

Gynecologic Oncology Network

🇺🇸

Greenville, North Carolina, United States

Stony Brook University Medical Center

🇺🇸

Stony Brook, New York, United States

Lehigh Valley Hospital-Cedar Crest

🇺🇸

Allentown, Pennsylvania, United States

Florida Gynecologic Oncology

🇺🇸

Fort Myers, Florida, United States

Northern Indiana Cancer Research Consortium

🇺🇸

South Bend, Indiana, United States

Maine Medical Center-Bramhall Campus

🇺🇸

Portland, Maine, United States

Advocate Christ Medical Center

🇺🇸

Oak Lawn, Illinois, United States

Chattanooga's Program in Women's Oncology

🇺🇸

Chattanooga, Tennessee, United States

University of Texas Medical Branch

🇺🇸

Galveston, Texas, United States

Diagnostic and Treatment Center

🇺🇸

Weston, Wisconsin, United States

Mercy Hospital Springfield

🇺🇸

Springfield, Missouri, United States

CoxHealth South Hospital

🇺🇸

Springfield, Missouri, United States

Pitt County Memorial Hosp Inc.

🇺🇸

Greenville, North Carolina, United States

FirstHealth of the Carolinas-Moore Regional Hosiptal

🇺🇸

Pinehurst, North Carolina, United States

Saint Michael's Hospital

🇺🇸

Stevens Point, Wisconsin, United States

Geisinger Medical Center

🇺🇸

Danville, Pennsylvania, United States

Greenville Health System Cancer Institute-Spartanburg

🇺🇸

Spartanburg, South Carolina, United States

Marshfield Clinic

🇺🇸

Marshfield, Wisconsin, United States

Geisinger Wyoming Valley/Henry Cancer Center

🇺🇸

Wilkes-Barre, Pennsylvania, United States

Marshfield Clinic - Weston Center

🇺🇸

Weston, Wisconsin, United States

Saint Dominic-Jackson Memorial Hospital

🇺🇸

Jackson, Mississippi, United States

Hackensack University Medical CCOP

🇺🇸

Hackensack, New Jersey, United States

Southeast Gynecologic Oncology Associates

🇺🇸

Knoxville, Tennessee, United States

UCLA / Jonsson Comprehensive Cancer Center

🇺🇸

Los Angeles, California, United States

Danbury Hospital

🇺🇸

Danbury, Connecticut, United States

Stanford Cancer Institute

🇺🇸

Palo Alto, California, United States

Medical Oncology and Hematology Associates-West Des Moines

🇺🇸

Clive, Iowa, United States

Mercy Cancer Center-West Lakes

🇺🇸

Clive, Iowa, United States

Long Beach Memorial Medical Center-Todd Cancer Institute

🇺🇸

Long Beach, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center

🇺🇸

Burbank, California, United States

Hartford Hospital

🇺🇸

Hartford, Connecticut, United States

Iowa Methodist Medical Center

🇺🇸

Des Moines, Iowa, United States

University of Massachusetts Memorial Health Care

🇺🇸

Worcester, Massachusetts, United States

Holy Cross Hospital

🇺🇸

Fort Lauderdale, Florida, United States

Iowa-Wide Oncology Research Coalition NCORP

🇺🇸

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates-Laurel

🇺🇸

Des Moines, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center

🇺🇸

Iowa City, Iowa, United States

University of Kentucky/Markey Cancer Center

🇺🇸

Lexington, Kentucky, United States

Norton Hospital Pavilion and Medical Campus

🇺🇸

Louisville, Kentucky, United States

Highlands Oncology Group PA - Fayetteville

🇺🇸

Fayetteville, Arkansas, United States

Saint Elizabeth Medical Center South

🇺🇸

Edgewood, Kentucky, United States

University of Arkansas for Medical Sciences

🇺🇸

Little Rock, Arkansas, United States

Olive View-University of California Los Angeles Medical Center

🇺🇸

Sylmar, California, United States

Memorial University Medical Center

🇺🇸

Savannah, Georgia, United States

University of California Davis Comprehensive Cancer Center

🇺🇸

Sacramento, California, United States

Colorado Gynecologic Oncology Group

🇺🇸

Aurora, Colorado, United States

University of Colorado Cancer Center - Anschutz Cancer Pavilion

🇺🇸

Aurora, Colorado, United States

Jupiter Medical Center

🇺🇸

Jupiter, Florida, United States

Northeast Georgia Medical Center

🇺🇸

Gainesville, Georgia, United States

Northwestern University

🇺🇸

Chicago, Illinois, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center

🇺🇸

Orange, California, United States

Woman's Hospital

🇺🇸

Baton Rouge, Louisiana, United States

Winthrop University Hospital

🇺🇸

Mineola, New York, United States

Augusta University Medical Center

🇺🇸

Augusta, Georgia, United States

Hurley Medical Center

🇺🇸

Flint, Michigan, United States

Medical Oncology and Hematology Associates-Des Moines

🇺🇸

Des Moines, Iowa, United States

Iowa Lutheran Hospital

🇺🇸

Des Moines, Iowa, United States

Tulane University Health Sciences Center

🇺🇸

New Orleans, Louisiana, United States

Washington Regional Medical Center - Fayetteville

🇺🇸

Fayetteville, Arkansas, United States

MedStar Washington Hospital Center

🇺🇸

Washington, District of Columbia, United States

Washington University School of Medicine

🇺🇸

Saint Louis, Missouri, United States

Yale University

🇺🇸

New Haven, Connecticut, United States

Columbia University/Herbert Irving Cancer Center

🇺🇸

New York, New York, United States

Baystate Medical Center

🇺🇸

Springfield, Massachusetts, United States

Sibley Memorial Hospital

🇺🇸

Washington, District of Columbia, United States

Memorial Medical Center

🇺🇸

Springfield, Illinois, United States

University of Massachusetts Medical School

🇺🇸

Worcester, Massachusetts, United States

The Hospital of Central Connecticut

🇺🇸

New Britain, Connecticut, United States

Nebraska Methodist Hospital

🇺🇸

Omaha, Nebraska, United States

University of New Mexico Cancer Center

🇺🇸

Albuquerque, New Mexico, United States

Mercy Medical Center-West Lakes

🇺🇸

West Des Moines, Iowa, United States

Our Lady Bellefonte Hospital

🇺🇸

Ashland, Kentucky, United States

Mercy Medical Center - Des Moines

🇺🇸

Des Moines, Iowa, United States

Dartmouth Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

University of Mississippi Medical Center

🇺🇸

Jackson, Mississippi, United States

CHRISTUS Highland Medical Center

🇺🇸

Shreveport, Louisiana, United States

Walter Reed National Military Medical Center

🇺🇸

Bethesda, Maryland, United States

University of Michigan Comprehensive Cancer Center

🇺🇸

Ann Arbor, Michigan, United States

Roswell Park Cancer Institute

🇺🇸

Buffalo, New York, United States

Novant Health Presbyterian Medical Center

🇺🇸

Charlotte, North Carolina, United States

Sanford Cancer Center-Oncology Clinic

🇺🇸

Sioux Falls, South Dakota, United States

University of Tennessee Health Science Center

🇺🇸

Memphis, Tennessee, United States

Methodist West Hospital

🇺🇸

West Des Moines, Iowa, United States

Lake University Ireland Cancer Center

🇺🇸

Mentor, Ohio, United States

East Tennessee State University

🇺🇸

Johnson City, Tennessee, United States

Keesler Medical Center

🇺🇸

Kessler AFB, Mississippi, United States

Gynecologic Oncology of West Michigan PLLC

🇺🇸

Grand Rapids, Michigan, United States

Rutgers New Jersey Medical School

🇺🇸

Newark, New Jersey, United States

UNC Lineberger Comprehensive Cancer Center

🇺🇸

Chapel Hill, North Carolina, United States

Wake Forest University Health Sciences

🇺🇸

Winston-Salem, North Carolina, United States

Medical University of South Carolina

🇺🇸

Charleston, South Carolina, United States

Sanford USD Medical Center - Sioux Falls

🇺🇸

Sioux Falls, South Dakota, United States

Carilion Clinic Gynecological Oncology

🇺🇸

Roanoke, Virginia, United States

Providence Regional Cancer System-Centralia

🇺🇸

Centralia, Washington, United States

Capital Medical Center

🇺🇸

Olympia, Washington, United States

Mount Sinai Medical Center

🇺🇸

New York, New York, United States

Women and Infants Hospital

🇺🇸

Providence, Rhode Island, United States

Greenville Health System Cancer Institute-Faris

🇺🇸

Greenville, South Carolina, United States

Hackensack University Medical Center

🇺🇸

Hackensack, New Jersey, United States

University of Missouri - Ellis Fischel

🇺🇸

Columbia, Missouri, United States

Cancer Research for the Ozarks NCORP

🇺🇸

Springfield, Missouri, United States

Avera Cancer Institute

🇺🇸

Sioux Falls, South Dakota, United States

Cooper Hospital University Medical Center

🇺🇸

Camden, New Jersey, United States

Texas Tech University Health Sciences Center

🇺🇸

Lubbock, Texas, United States

Saint Louis University Hospital

🇺🇸

Saint Louis, Missouri, United States

Carolinas Medical Center/Levine Cancer Institute

🇺🇸

Charlotte, North Carolina, United States

Legacy Good Samaritan Hospital and Medical Center

🇺🇸

Portland, Oregon, United States

Brooke Army Medical Center

🇺🇸

Fort Sam Houston, Texas, United States

Wilford Hall Medical Center

🇺🇸

Lackland AFB, Texas, United States

Cancer Care Associates-Midtown

🇺🇸

Tulsa, Oklahoma, United States

Oklahoma Cancer Specialists and Research Institute-Tulsa

🇺🇸

Tulsa, Oklahoma, United States

Akron General Medical Center

🇺🇸

Akron, Ohio, United States

Geisinger Medical Group

🇺🇸

State College, Pennsylvania, United States

Compass Oncology Rose Quarter

🇺🇸

Portland, Oregon, United States

Northwest Medical Specialties PLLC

🇺🇸

Tacoma, Washington, United States

Saint Luke's University Hospital-Bethlehem Campus

🇺🇸

Bethlehem, Pennsylvania, United States

Scott and White Memorial Hospital

🇺🇸

Temple, Texas, United States

Marshfield Clinic Cancer Center at Sacred Heart

🇺🇸

Eau Claire, Wisconsin, United States

Providence - Saint Peter Hospital

🇺🇸

Olympia, Washington, United States

Saint Clare Hospital

🇺🇸

Lakewood, Washington, United States

Abington Memorial Hospital

🇺🇸

Abington, Pennsylvania, United States

West Penn Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Marshfield Clinic-Minocqua Center

🇺🇸

Minocqua, Wisconsin, United States

University Medical Center Brackenridge

🇺🇸

Austin, Texas, United States

Saint Joseph's Hospital

🇺🇸

Marshfield, Wisconsin, United States

Aurora Sinai Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Black Hills Obstetrics and Gynecology

🇺🇸

Rapid City, South Dakota, United States

The Don and Sybil Harrington Cancer Center

🇺🇸

Amarillo, Texas, United States

Covenant Medical Center-Lakeside

🇺🇸

Lubbock, Texas, United States

Sacred Heart Hospital

🇺🇸

Eau Claire, Wisconsin, United States

Saint Francis Hospital

🇺🇸

Federal Way, Washington, United States

Marshfield Clinic at James Beck Cancer Center

🇺🇸

Rhinelander, Wisconsin, United States

Virginia Oncology Associates-Hampton

🇺🇸

Hampton, Virginia, United States

Multicare Health System

🇺🇸

Tacoma, Washington, United States

MultiCare Good Samaritan Hospital

🇺🇸

Puyallup, Washington, United States

University of Wisconsin Hospital and Clinics

🇺🇸

Madison, Wisconsin, United States

Froedtert and the Medical College of Wisconsin

🇺🇸

Milwaukee, Wisconsin, United States

MultiCare Auburn Medical Center

🇺🇸

Auburn, Washington, United States

MultiCare Tacoma General Hospital

🇺🇸

Tacoma, Washington, United States

Marshfield Clinic - Ladysmith Center

🇺🇸

Ladysmith, Wisconsin, United States

Marshfield Clinic - Wisconsin Rapids Center

🇺🇸

Wisconsin Rapids, Wisconsin, United States

MultiCare Allenmore Hospital

🇺🇸

Tacoma, Washington, United States

Northwest NCI Community Oncology Research Program

🇺🇸

Tacoma, Washington, United States

Saint Joseph Medical Center

🇺🇸

Tacoma, Washington, United States

Aurora Saint Luke's Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Marshfield Clinic Cancer Care at Saint Michael's Hospital

🇺🇸

Stevens Point, Wisconsin, United States

Marshfield Clinic-Wausau Center

🇺🇸

Wausau, Wisconsin, United States

Marshfield Clinic-Rice Lake Center

🇺🇸

Rice Lake, Wisconsin, United States

Marshfield Clinic-Chippewa Center

🇺🇸

Chippewa Falls, Wisconsin, United States

Aurora West Allis Medical Center

🇺🇸

West Allis, Wisconsin, United States

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