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Feasibility Study and Preliminary Application Study on Iris OCTA

Conditions
Glaucoma
Diabetic Retinopathy
Retinal Neovascularization, Unspecified
Myopia
Retinal Detachment
Conjunctivitis
Uveitis
Registration Number
NCT03631108
Lead Sponsor
Shanghai Eye Disease Prevention and Treatment Center
Brief Summary

All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens. The main outcomes are iris blood flow density and vascular density.

Detailed Description

1. Feasibility study of iris OCTA technology

2. Establishment of iris OCTA database in normal population and analysis of related factors: (1) different sex; (2) different age; (3) different myopic diopter; (4) 24-hour diurnal changes from morning to night; (5) before and after mydriasis; (6) different blood pressure; (7) different intraocular pressure; (8) different blood glucose; (9) before and after exercise. (10) drinking water, tea, coffee and red wine.

3. Analysis of iris OCTA data related to eye diseases:(1) conjunctivitis; (2) glaucoma; (3) childhood myopia; (4) uveitis; (5) diabetic retinopathy; (6) retinal detachment; (7) fundus neovascularization.

4. Influence of commonly used ophthalmic drops on iris OCTA data. Observe the difference of iris OCTA test data before and after treatment: (1) conjunctivitis treated with levofloxacin antibiotics; (2) glaucoma treated with prostaglandins, adrenalines and receptor blockers; (3) childhood myopia treated with atropine drugs (4) uveitis treated with hormonal drugs. (5) diabetic retinopathy treated with vasodilator.

5. Effect on iris OCTA data before and after ophthalmic surgery. (1) cataract, phacoemulsification + intraocular lens implantation; (2) glaucoma, iridectomy; (3) fundus neovascularization, intraocular injection of anti-VEGF; (4) diabetic retinopathy, vitreous surgery.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
4000
Inclusion Criteria
  • Healthy volunteers and ophthalmological patients who can understand and agree to cooperate this study will be included.
Exclusion Criteria
  • Patients who can not cooperate with the examination.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Iris Vessel Geometric Characteristics0:00 8:00 14:00 20:00

Iris vascular density and neovascular density

Secondary Outcome Measures
NameTimeMethod

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