Hemodynamic Effects of Inhaled Milrinone versus Inhaled Nitroglyceri

Not Applicable

• Conditions: Circulatory System; Cardiology; Anaesthesia; Surgery

• Registration Number: PACTR202106565996138
• Lead Sponsor: Faculty of Medicine Ain shams university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-15
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

?Age between 18-65 years old.
?Patients with preoperative mitral valve disease (isolated mitral stenosis, regurgitation or combined stenosis and regurgitation) with pulmonary hypertension (mean pulmonary arterial pressure > 40 mmHg) admitted to postoperative ICU after already performed elective mitral valve replacement surgery.
?Both genders.
?Left ventricular ejection fractions over 40%.

Exclusion Criteria

?Patient undergoing emergency surgery.
?Redo surgeries.
?History of chronic obstructive pulmonary disease, severe renal disease, liver dysfunction, coagulopathy or thrombocytopenia.
?Patients with thromboembolic disease treated with anticoagulation therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
oHemodynamic parameters including: heart rate, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, central venous pressure, systolic pulmonary artery pressure, diastolic pulmonary artery pressure, mean pulmonary artery pressure, ejection fraction and fractional shortening.

Secondary Outcome Measures

Name	Time	Method
oArterial and central venous blood samples will be obtained during each assessment point and immediately analyzed and arterial oxygen tension/fraction of inspired oxygen (PaO2/FiO2) ratio will be calculated by standard formulas.