Investigation of multispectral photoacoustic tomography (MSOT) as an additional method to ultrasound diagnosis in melanoma follow-up patients for differentiation of lymph node metastases to Covid-19 vaccination associated lymphadenopathy
- Conditions
- C43Malignant melanoma of skin
- Registration Number
- DRKS00026798
- Lead Sponsor
- niklinik Essen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 320
Patients with a history of melanoma who require regular lymph node ultrasonography according to the guidelines and who currently show a sonographic suspicion of lymph node metastasis. Furthermore, patients must have received an mRNA-based Covid-19 vaccination within the last 8 weeks.
Patients with the presence of melanoma disease who require regular lymph node sonography in accordance with national guidelines and have sonographically unremarkable lymph nodes. Furthermore, patients must have received an mRNA-based Covid-19 vaccination within the last 8 weeks.
Insufficient ability to communicate in the German language or lack of understanding of the German language
(Functional) illiteracy
Lacking or missing capacity of the patient to give consent
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Significant differences in ratios of oxy- /deoxyhemoglobin and melanin content in patients with melanoma lymph node metastases and in patients with reactive lymph node lesions after Covid-19 vaccination.
- Secondary Outcome Measures
Name Time Method Correlation of detected differences in oxygenation and melanin content to other patient characteristics such as age, gender, tumor characteristics (tumor stage, mutation status of the tumor, histological characteristics such as PD-L1 expression of the tumor).