the role of subcutaneous and visceral fat tissue in the mechanism of obesity induced insulin resistance
Completed
- Conditions
- insulin resistance and diabetes1001842410022958
- Registration Number
- NL-OMON31248
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 250
Inclusion Criteria
healthy women between 18-75 years of age undergoing abdominal surgery for gynaecological diseases
Exclusion Criteria
fever
dissiminated gynaecological oncolocgical disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The comparison of subcutaneous and visceral tissue in the following subanalyses:<br /><br>Quantitative proteomics for the comparison of different secretomes (n=30)<br /><br>Interactions of macrophages and adipocytes in human fat tissue (n=60)<br /><br>Interactions between bowel hormones and short chain fatty acids and fat tissue<br /><br>(n=60)<br /><br>production of exosomes by fat tissue (n=50)<br /><br>validation of the proteins found in relation with BMI (n=50)<br /><br>correlation of the scretomes with serum levels</p><br>
- Secondary Outcome Measures
Name Time Method <p>see above</p><br>