Opioid-free general anesthesia for Transthoracic Oesophagectomy; Does it improve postoperative analgesia and other recovery criteria? A prospective randomized study
Not Applicable
- Conditions
- Anaesthesia
- Registration Number
- PACTR202010907549506
- Lead Sponsor
- Tamer Nabil Abdelrahman
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Patients age range between 18- 64 years
candidates for elective transthoracic oesophagectomy
forced vital capacity (FVC) or force expiratory volume 1 (FEV1) = 60% of the predicted values.
Exclusion Criteria
Patients age below 18 years or above 64 years old
History of thoracic trauma
FVC or FEV1 = 60% of predicted values
History of obstructive sleep apnea or need for home CPAP mask
Severe hypertension
Uncontrolled diabetes mellitus
Severe cardiovascular, renal or hepatic diseases
History of analgesic administration or intake during past 24 hours
Pregnant females
History of relevant drug allergy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary goal of this study will be assessment of the effectiveness of OFA in transthoracic oesophagectomy in comparison with opioid-based technique (OBA) regarding the postoperative pain profile assessed by the visual analogue score (VAS) for 6 hours (0 = no pain, 1 - 3 = mild pain, 4 - 6 = moderate pain, 7 - 10 = severe pain)
- Secondary Outcome Measures
Name Time Method Respiratory rate and oxygen saturation will be recorded immediately before and after extubation and every 10 minutes for 30 minutes postoperative then it will be recorded every hour for the next 6 hours in the ICU.;Postoperative hemodynamics including mean heart rate (bpm) and MAP (mmHg) which will be recorded from the immediate postextubation, and every hour till the next 6 hours postoperatively;The incidence of postoperative hypoxia (Spo2= 90%) to which oxygen (6-10 L) via face mask will be applied during the first 6 hours postoperative and according to response to this step the patients will be assessed clinically by (respiratory rate, Spo2, ABG) for the need of mechanical ventilation either invasive or non-invasive.;Incidence of postoperative nausea and vomiting during the first 6 hours which will be treated by granisetrone 1mg intravenous.