ISRCTN06886935
Completed
未知
Development and evaluation of an intervention based around the national guidelines on the management of suspected encephalitis, and its evaluation through a cost-effectiveness analysis
niversity of Liverpool (UK)0 sites1,680 target enrollmentJuly 22, 2013
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Liverpool (UK)
- Enrollment
- 1680
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
2015 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/25623603 2015 results in: http://www.implementationscience.com/content/10/1/37 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30521521
Investigators
Eligibility Criteria
Inclusion Criteria
- •Site inclusion criteria:
- •All centres will have a consultant and all centres must be equipped with the ability to perform, or have access to CT/MRI scans and have aseptic conditions for conducting a LP to be performed. Hospitals will be randomised as a unit to either the standard care or intervention arm. Study centres will be initiated once all global (e.g. local research and development \[R\&D] approval) and study\-specific conditions (e.g. training requirements) have been met, and all necessary documents have been returned to the Brain Infections UK coordinating centre.
- •Within this study, any patients who have suspected encephalitis within the recruited sites will be included in the study. The inclusion criteria for suspected encephalitis are:
- •Patients with suspected encephalitis
- •(a) Mandatory
- •Acute or sub\-acute (\<4 weeks) alteration in consciousness, cognition, personality or behaviour persisting for more than 24 hours. Personality/behaviour change includes: agitation, psychosis, somnolence, insomnia, catatonia, mood liability, altered sleep pattern and (in children): new onset enuresis, or irritability.
- •Plus ANY two of:
- •1\. Fever (\> 38ºC) / prodromal illness ? acute or sub\-acute
- •2\. Seizures: new onset
- •3\. Focal neurological signs ? acute or sub\-acute onset. These include:
Exclusion Criteria
- •Site exclusion criteria:
- •Current participation in the ENCEPH UK programme
- •Added 07/01/2015:
- •Patient exclusion criteria
- •Any patient aged under 28 days upon the date of admission shall be excluded
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Education programme (DESMOND-ID) for the self-management of type 2 diabetes for adults with intellectual disabilities (ID)Type 2 diabetesNutritional, Metabolic, EndocrineISRCTN93185560niversity of Ulster (UK)72
Completed
Not Applicable
Examining the effectiveness of a self-help psychoeducation programme on outcomes of outpatients with coronary heart disease (CHD)ISRCTN15839687ational University Health System (Singapore)129
Completed
Not Applicable
Investigating the timing of high dose rate (HDR) brachytherapy with external beam radiation therapy (EBRT) in intermediate and high risk localised prostate cancer patients and its effects on toxicity and quality of lifeProstate cancerCancerISRCTN15835424Southend University Hospital NHS Foundation Trust50
Completed
Phase 1
Study to evaluate the use of allogeneic mesenchymal stromal cells for the treatment of skin disease in children with recessive dystrophic epidermolysis bullosaRecessive dystrophic epidermolysis bullosaSkin and Connective Tissue DiseasesEpidermolysis bullosaISRCTN46615946King's College London (UK)10
Completed
Not Applicable
The use of compression bandages in total knee replacement surgeryISRCTN86903140orthumbria Healthcare NHS Foundation Trust (UK)50