Clinical trial of the effectiveness of oral clonidine on pain severity and morphine requirement in patients with orthopedic fractures

Phase 2

Recruiting

• Conditions: Bone fracture.; Fracture of bone following insertion of orthopedic implant, joint prosthesis, or bone plate; M96.6

• Registration Number: IRCT20220822055774N1
• Lead Sponsor: Kerman University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 November 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

Patients over 18 years old with bone fractures, and pain score >5 based on VASS
History of opioid drug abuse
Consent to participate in the study

Exclusion Criteria

Pregnancy and breastfeeding women
History of underlying cardio-pulmonary, renal diseases
high blood pressure
Thrombocytopenia
Asthma
Use of narcotics other than morphine
The patient's urgent need for blood transfusion or resuscitation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: Before the intervention and 30 minutes, 1 hour, 3 hours and 6 hours after the intervention. Method of measurement: Visual pain intensity measurement scale.

Secondary Outcome Measures

Name	Time	Method
Hemodynamic symptoms (systolic and diastolic blood pressure, heart rate, arterial blood oxygen saturation). Timepoint: Before the intervention and 30 minutes, 1 hour, 3 hours and 6 hours after the intervention. Method of measurement: Monitoring device.