To study the effect of clonidine on pulse rate and blood pressure after introducing a tube into the throat during general anaesthesia
Phase 1
- Conditions
- Health Condition 1: null- ASA PS 1 & 2 patients coming for elective surgeries requiring general anaesthesia with endo tracheal intubation
- Registration Number
- CTRI/2018/03/012716
- Lead Sponsor
- Mahitha Namburu
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients aged between 18-65 years belonging to ASA physical status 1or 2 of either gender undergoing surgical procedures under general anaesthesia requiring endotracheal intubation
Exclusion Criteria
Patients with hypertension, Ischemic heart disease, BMI >25, Patients on beta blockers
Patients with known or anticipated difficult airway, Duration of Laryngoscopy >1Min
More than 1 attempt at intubation, Laryngoscopic grade >2B
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Oral Clonidine is expected to attenuate the hemodynamic stress response ( i.e., increse in heart rate and blood pressure) to laryngoscopy and intubation but with lesser incidence of adverse effects like bradycardia and hypotension as seen with intravenous clonidineTimepoint: Duration of laryngoscopy and intubation (from the time laryngoscope inserted till the end tidal CO2 is seen on the monitor) is noted; grade of laryngoscopy, heart rate, systolic , diastolic and mean blood pressures are noted at the time of induction, just before laryngoscopy, immediately after and, 1,3,5,15 and 30 mins after intubation are noted.
- Secondary Outcome Measures
Name Time Method Incidence of bradycardia and hypotensionTimepoint: heart rate, systolic , diastolic and mean blood pressures are noted at the time of induction, just before laryngoscopy, immediately after intubation, 1,3,5,15 and 30mins after intubation