NCT02202941已完成不适用
Effect of Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients in Korea
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 6
- 主要终点
- Duration of antibiotic treatment
研究概览
简要总结
This clinical trial is aimed to show a procalcitonin-guided treatment algorithm may shorten duration of antibiotic therapy safely and cost-effectively in sepsis patients of Korean ICU.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with suspicious or confirmed sepsis at admission or during stay in ICU
- •Patients with antibiotic duration of less than 48 hours before enrollment
排除标准
- •Age less than or equal to 18 years
- •Known pregnancy
- •Specific infections for which long-term antibiotic treatment for 3 weeks more is strongly recommended: infective endocarditis, empyema, osteomyelitis et al.
- •severe immunocompromised patients : HIV infected patients (CD4 count < 200 cells/mm3), Neutropenia (ANC count < 500/mm3)
- •Presence of do-not-resuscitate order
研究组 & 干预措施
Procalcitonin guided treatment
Experimental
Patients who will be randomized to this arm will receive antibiotics therapy based on procalcitonin-guided algorithm.
干预措施: Procalcitonin guided treatment (Other)
Conventional treatment
Active Comparator
Patients who will be randomized to this arm will receive antibiotic therapy based on conventional practice.
干预措施: Conventional treatment (Other)
结局指标
主要结局
Duration of antibiotic treatment
时间窗: up to 28 days
次要结局
- Clinical response to treatment for infection(up to 28 days)
- In hospital mortality(up to 90 days)
- All cause mortality(up to 28 days)
- In ICU mortality(up to 28 days)
研究者
Sang-Min Lee
Associate professor
Seoul National University Hospital
研究点 (6)
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