Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients
Not Applicable
Completed
- Conditions
- Sepsis
- Registration Number
- NCT02202941
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
This clinical trial is aimed to show a procalcitonin-guided treatment algorithm may shorten duration of antibiotic therapy safely and cost-effectively in sepsis patients of Korean ICU.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- All patients with suspicious or confirmed sepsis at admission or during stay in ICU
- Patients with antibiotic duration of less than 48 hours before enrollment
Exclusion Criteria
- Age less than or equal to 18 years
- Known pregnancy
- Specific infections for which long-term antibiotic treatment for 3 weeks more is strongly recommended: infective endocarditis, empyema, osteomyelitis et al.
- severe immunocompromised patients : HIV infected patients (CD4 count < 200 cells/mm3), Neutropenia (ANC count < 500/mm3)
- Presence of do-not-resuscitate order
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Duration of antibiotic treatment up to 28 days
- Secondary Outcome Measures
Name Time Method Clinical response to treatment for infection up to 28 days success vs failure vs relapse after treatment
In hospital mortality up to 90 days All cause mortality up to 28 days In ICU mortality up to 28 days
Trial Locations
- Locations (4)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital🇰🇷Seoul, Korea, Republic of