NCT01494675已完成不适用
Clinical Impact of Procalcitonin to Shorten Antimicrobial Therapy in Septic Patients With Proven Bacterial Infection in an Intensive Care Setting
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 81
- 试验地点
- 2
- 主要终点
- reducing the duration of antibiotic therapy
研究概览
简要总结
Recently, biomarkers like procalcitonin have been studied in order to help physicians to decrease the duration of the antibiotic therapy. The investigators objective was to assess whether the decrease in procalcitonin levels could be used to reduce the antibiotic therapy in critically ill patients with a proven infection without risking a worse outcome.
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients admitted in the intensive care unit with sepsis, severe sepsis and septic shock with a microbiologically confirmed infection (blood, urine, tracheal aspirate or bronchoalveolar fluid culture)
排除标准
- •onset of the antibiotic therapy more than 48 hours before the date when the cultures were performed
- •patients less than 18 years old
- •known pregnancy
- •infections requiring prolonged antibotic therapy such as endocarditis, hepatic or brain abscess, deep abscess, mediastinitis and osteomyelitis
- •severe infection caused by virus, parasites, fungi or chronic prostatitis
- •negative cultures in patients with suspected sepsis, severe sepsis or septic shock
结局指标
主要结局
reducing the duration of antibiotic therapy
时间窗: 2 years
the primary objective was to assess if a procalcitonin measurement protocol can reduce the duration of antibiotic therapy in critically ill patients with sepsis, severe sepsis and septic shock with documented infection
次要结局
- all cause mortality(2 years)
研究者
Rodrigo Octavio Deliberato
ICU staff physician at Hospital Israelita Albert Einstein
Hospital Israelita Albert Einstein
研究点 (2)
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