Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy

Phase 4

Completed

• Conditions: Acute Pain
• Interventions: Drug: standard general anesthesia; Drug: Transversus Abdominis Plane Block

• Registration Number: NCT02645903
• Lead Sponsor: Inonu University

Brief Summary

Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in liver transplantation donors in whom a right lateral extending upper mid-line abdominal incision was used.

Detailed Description

This prospective randomized controlled double-blinded study was conducted with 50 liver transplantation donors between 18-65 years who were scheduled to undergo right hepatectomy surgery. Cases to whom TAP block with ultrasound was applied after standard general anesthesia were determined as Group 1 and cases to whom only standard general anesthesia was applied, were determined as Group 2.

Study Timeline

• Study Start: 2015-05
• Primary Completion: 2015-10
• Study Completion: 2015-10
• Study First Submitted: 2015-12-24
• Study First Submitted QC: 2015-12-31
• Status Verified: 2016-01
• Study First Posted: 2016-01-05
• Last Update Submitted: 2016-01-05
• Last Update Posted: 2016-01-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Liver transplantation donors

Exclusion Criteria

• Patients with a history of allergy to the drugs used in the study protocol, coagulation pathology, opioid tolerance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
nonblocked	standard general anesthesia	Patients who received standard general anesthesia alone made up Group 2. Postoperative analgesia was administered through a morphine the patient-controlled analgesia device.
transversus abdominis plane block	Transversus Abdominis Plane Block	Patients who received a tranversus abdominis plane block with ultrasound after standard general anesthesia represented Group 1. The tranversus abdominis plane block was performed bilaterally by obtaining an image with real time ultrasound guidance with a 6-13 MHz linear probe. The block was placed with a 22 G 80 mm needle while obtaining real-time images via an in-plane technique. Two 20 mL syringes were prepared after preparing a local anesthetic concentration of 1.5 mg/kg of 0.5% bupivacaine to 40 mL with saline. These were administered to the left and right abdominal walls. Postoperative analgesia was administered through a morphine the patient-controlled analgesia device.

Primary Outcome Measures

Name	Time	Method
pain scores (at movement and at rest)	postoperatively at 24 hours	Pain scores were assessed using a visual analog scale (0: No pain, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10: Excruciating pain).

Secondary Outcome Measures

Name	Time	Method
morphine consumption	postoperatively at 24 hours	morphine consumption were measured in postoperatively 24 hours