Oro-gastro-intestinal digestion of emulsified fat and how this digestion relates to colloidal stability and physiological responses

Withdrawn

Conditions: gastric emptying
satiety
10017977

Registration Number: NL-OMON35019

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 18

Inclusion Criteria

Sex: male and female
age: 18-55 years
BMI: 18-29kg/m2

Exclusion Criteria

Evidence of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/ connective tissue, musculoskeletal, metabolic/nutritional, endocrine, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter/endpoint<br /><br><br /><br>The main study parameter is the amount of fatty acids released after an<br /><br>intragastric fat load of well-emulsified fat</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary parameters are;<br /><br>- Differences in fatty acid release between an intragastric load of<br /><br>non-emulsified vs. well-emulsified fat<br /><br>- Differences in fatty acid release after oral vs. gastric vs. duodenal<br /><br>administration of well-emulsified fat<br /><br>- Colloidal behaviour (droplet size, flocculation, aggregation, coalescence) in<br /><br>the oral, gastric and duodenal compartment<br /><br>- Lipase activity<br /><br>- Gastric emptying, small bowel transit time<br /><br>- Gut hormones: hormones CCK (blood), GLP-1 (blood) ,PYY (blood en saliva),<br /><br>ghrelin (blood and saliva)<br /><br>- Satiety: VAS (visual analogue scale)<br /><br>- Energy intake at a subsequent meal<br /><br>- Gallbladder motility/ emptying</p><br>