Effect of Monosaccharides on Intestinal Barrier Function
Not Applicable
Completed
- Conditions
- EndotoxemiaDietary Habits
- Interventions
- Other: Dietary Intervention
- Registration Number
- NCT03482284
- Lead Sponsor
- Prof. Dr. Ina Bergheim
- Brief Summary
The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.
- Detailed Description
In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- BMI <25 kg/m2
- no kown history of metabolic disorders or fatty liver
Exclusion Criteria
- food allergies or intolerances (esp. fructose intolerance and malabsorption)
- renal insufficiency
- chronic disease of the gastrointestinal tract
- taking drugs affecting lipid or glucose metabolism
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Monosaccharide 1 Dietary Intervention Participants receive standardized meals with a defined amount of monosaccharide 1. Monosaccharide 2 Dietary Intervention Participants receive standardized meals with a defined amount of monosaccharide 2.
- Primary Outcome Measures
Name Time Method Changes in parameters of intestinal barrier function 1 week Changes in endotoxin plasma levels
- Secondary Outcome Measures
Name Time Method Changes in blood pressure 1 week Changes in systolic and diastolic blood pressure
Changes in markers for glucose metabolism 1 week Changes in fasting glucose and fasting insulin levels
Changes in blood lipid levels 1 week Changes in triglyceride levels
Changes in Uric Acid levels 1 week Changes in Uric Acid blood levels