TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
Recruiting
- Conditions
- Cardiovascular Diseases
- Registration Number
- NCT00985049
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 350
Inclusion Criteria
- Aged greater than 20 years
- Undergoing aortic valve surgery with or without CABG surgery
- Receive and apical vent as part of the surgery
Exclusion Criteria
- Will not receive an apical left ventricular vent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differential gene expression Immediate
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States