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Influence of continuous infusion of low-dose human atrial natriuretic peptide on renal function during cardiac surgery

Phase 2
Conditions
myocardial infarction, angina, valvular disease, thoracic aortic aneurysm
Registration Number
JPRN-UMIN000001440
Lead Sponsor
ihon University School of Medicine
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Complete: follow-up complete
Sex
All
Target Recruitment
700
Inclusion Criteria

Not provided

Exclusion Criteria

renal impairment(Cr>1.3mg/dl) cardiogenic shock

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
mortality complication Incidence of postoperative acute renal failure maximum value and percent increase of Cr.
Secondary Outcome Measures
NameTimeMethod
pre-op, 0,1,3,7 days after surgery: ANP, renin activity, angiotensin II, aldosterone, blood urea nitrogen (BUN), Cr, sodium (Na), osmotic pressure (Osm),Urinary Na (U-Na), urinary Cr (U-Cr), and osmotic pressure (U-osm) . pre-op, 0,1,3,7 days after surgery: creatinine clearance Ccr, fractional sodium excretion, free water clearance and renal failure index.
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