Genetic and Phenotypic Characteristics of Mitral Valve Prolapse

• Conditions: Mitral Valve Prolapse; Genetic Disease

• Registration Number: NCT03884426
• Lead Sponsor: Nantes University Hospital

Brief Summary

Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.

Detailed Description

After clinical identification of patients with MVP, doctors organize 1st degree relative familial screening. A comprehensive echocardiography was carried out along with clinical examination. All echo data were stored for off-line analysis by a sonographer in our Core-lab. Blood was sample at the time of echocardiography in adult patients for DNA analyses. Follow-up for mitral valve changes will be performed after 5 years.

Study Timeline

• Study Start: 2010-12
• Study First Submitted: 2013-03-21
• Study First Submitted QC: 2019-03-19
• Study First Posted: 2019-03-21
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-27
• Last Update Posted: 2021-08-30
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Patients of any age
• with typical mitral valve prolapse
• relatives examined during familial screening

Exclusion Criteria

• Refusal of the patient

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MVP defined by a superior displacement of at least 2 mm	At Day 0	MVP defined by a superior displacement of at least 2 mm

Secondary Outcome Measures

Name	Time	Method
Comprehensive mitral valve apparatus characterization per size of items (leaflets, chordae, annulus)	At Day 0	Leaflets length ; Chordae length ; Annulus diameter
Comprehensive mitral valve apparatus characterization per other items (papillary muscle, ventricles)	At Day 0	Papillary muscles aspect ; Right Ventricle function ; Left Ventricle Ejection Fraction
Comprehensive mitral valve apparatus characterization per size of items (ventricle and atrium sizes)	At Day 0	Left ventricle and atrium sizes ; right ventricle size ; right Atrium size
Comprehensive mitral valve apparatus characterization per size of items	At Day 0	Leaflets thickness

Trial Locations

Locations (3)

Nantes University Hospital; 🇫🇷 Nantes, France

Rennes University Hospital; 🇫🇷 Rennes, France

Brest University Hospital; 🇫🇷 Brest, France