Genetic Basis of Mitral Valve Prolapse

Recruiting

• Conditions: Mitral Valve Prolapse

• Registration Number: NCT01719211
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.

Detailed Description

This is a genome-wide association study.

Study Timeline

• Study Start: 1999-01
• Study First Submitted: 2012-10-30
• Study First Submitted QC: 2012-10-31
• Study First Posted: 2012-11-01
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-07
• Last Update Posted: 2023-11-08
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Mitral valve prolapse

Exclusion Criteria

• Other mitral valve diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Discovery of the genetic basis of Mitral Valve Prolapse	5 years	Genome-wide association

Trial Locations

Locations (1)

Mass General Hospital; 🇺🇸 Boston, Massachusetts, United States