Genetics of pelvic organ prolapse; identification of specific gene defects in patients and their family members.

• Conditions: Pelvic floor, pelvic organ prolapse, genetic polymorphism, collagen

• Registration Number: NL-OMON21396
• Lead Sponsor: one

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Other
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

First and second degree relatives of patients with COL3A1 polymorphism.

Exclusion Criteria

1. Genetic diseases with a known increased risk of POP (such as Ehlers Danlos, Marfan and Steinert’s disease);

2. Problems with regards to the patient’s understanding of the study;

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The presence of the COL3A1 polymorphism in first and second degree family members of the index patients with the homozygous COL3A1 polymorphism.

Secondary Outcome Measures

Name	Time	Method
The presence of pelvic organ prolapse and related conditions (such as inguinal hernia) in first and second degree family members of the index patients with the homozygous COL3A1 polymorphism.