Effect of palonosetron on postoperative nausea and vomiting (comparison with ondansetron and ramosetron)

Not Applicable

Recruiting

• Conditions: Not Applicable

• Registration Number: KCT0000012
• Lead Sponsor: The Catholic University of Korea, Seoul St. Mary's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

Patients undergoing thyroid surgery, with a risk of PONV exceeding 60% are selected according to the expected risk for PONV using the simplified risk score of Apfel et al. The 4 risk factors considered in this score are female gender, nonsmoking, the use of postoperative opioids, and prior history of motion sickness or PONV; the presence of 0, 1, 2, 3, or 4 of these risk factors correspond to approximately 10, 20, 40, 60, and 80% risk for PONV, respectively. Basic inclusion criteria are nonsmoking, female patients, and use of postoperative opioid.

Exclusion Criteria

Patients who have severe impairment of bowel motility, insulin-dependent diabetes mellitus, pregnancy or breastfeeding, administration of antiemetic medication within 24 hours before surgery, systemic treatment with steroids within 24 hours before surgery or during 48 hours after surgery, obesity (body mass index >=35 kg/m2),impaired renal and/or hepatic function, or require radical neck dissection

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence and severity of postoperative nausea and vomiting

Secondary Outcome Measures

Name	Time	Method
requirement for anti-emetic rescue medication ;pain degree (Visual analogue scale) and requirement for analgesic rescue medication;total dose of fentanyl used in intravenous patient-controlled analgesia;Incidence of side effects (Headache, dizziness, and drowsiness)