Lexiscan(TM) Rb-82 Myocardial Perfusion PET: A Comparison With Dipyridamole Stress

Phase 4

• Conditions: Coronary Artery Disease
• Interventions: Drug: Rest/Dipyridamole Stress Rb-82 Myocardial Perfusion PET/CT; Drug: Rest/Lexiscan(TM) Stress Rb-82 Myocardial Perfusion PET

• Registration Number: NCT00808314
• Lead Sponsor: Cardiovascular Imaging Technologies

Brief Summary

Lexiscan(TM) has ideal properties for Rb-82 PET imaging and the stress response it invokes may offer multiple advantages for the diagnosis of coronary disease and functional abnormalities. The goal of this investigation is to establish quantitative equivalence of Lexiscan(TM) rest/stress Rb-82 PET images to dipyridamole rest/stress images.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-12
• Study First Submitted: 2008-12-12
• Study First Submitted QC: 2008-12-12
• Study First Posted: 2008-12-15
• Primary Completion: 2010-12
• Status Verified: 2012-08
• Last Update Submitted: 2012-08-01
• Last Update Posted: 2012-08-02
• Study Completion: 2012-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• BMI <35
• No intervention or change in management between dipyridamole and Lexiscan(TM) PET

Exclusion Criteria

• BMI >35
• An intervention or change in management between dipyridamole and Lexiscan(TM) PET

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LL for CAD	Rest/Dipyridamole Stress Rb-82 Myocardial Perfusion PET/CT	Subjects with \<5% pre-test low likelihood for CAD based on Diamond and Forrester criteria will be recruited to undergo both rest/stress dipyridamole PET followed by a rest/stress Lexiscan(TM) PET with 30 days.
LL for CAD	Rest/Lexiscan(TM) Stress Rb-82 Myocardial Perfusion PET	Subjects with \<5% pre-test low likelihood for CAD based on Diamond and Forrester criteria will be recruited to undergo both rest/stress dipyridamole PET followed by a rest/stress Lexiscan(TM) PET with 30 days.
CAD	Rest/Lexiscan(TM) Stress Rb-82 Myocardial Perfusion PET	Subjects with existing mild-moderate ishemia demonstrated by a recent (\< 1 month) rest/stress dipyridamole PET will undergo a rest/stress Lexiscan(TM) PET.

Primary Outcome Measures

Name	Time	Method
Quantitative analysis of local and regional myocardial perfusion between Lexiscan(TM) and dipyridamole rest/stress Rb82 PET	12 months

Trial Locations

Locations (1)

Saint Luke's Cardiovascular Consultants; 🇺🇸 Kansas City, Missouri, United States