Use of Lexiscan for Myocardial Stress Perfusion Computed Tomography With a 3rd Generation Dual Source CT System
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Number of Treatment-related Adverse Events
研究概览
简要总结
The purpose of this study is to evaluate the feasibility, tolerability, safety, and image quality of low-radiation, dynamic perfusion CT of the heart in patients with suspected ischemic chest pain and a moderate or severe stenosis seen on coronary CTA. Secondary aims include the assessment of the diagnostic accuracy of CT perfusion imaging compared to either SPECT or invasive angiography.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject must present with symptoms (e.g. chest pain) suspicious for cardiac ischemia as determined by treating physician.
- •Subject must have been referred for cardiac CT angiography OR subject must have undergone clinically indicated SPECT with positive or equivocal findings OR subject must have undergone clinically indicated SPECT with prior cardiac CT angiography that showed moderate or severe stenosis.
- •Subject must be 18 - 85 years of age.
- •Subject must provide written informed consent prior to any study-related procedures being performed.
- •Subject must be willing to comply with all clinical study procedures.
排除标准
- •Subject is a pregnant or nursing female. Exclude the possibility of pregnancy:
- •By testing (serum or urine beta HCG) within 24 hours before study agent administration, or
- •By surgical sterilization, or
- •Post menopausal, with minimum one (1) year history without menses.
- •Subject has severe asthma or COPD requiring frequent inhaler use.
- •Subject has prior diagnosis of obstructive CAD that has not been revascularized.
- •Subject with implanted rhythm devices (pacemaker, defibrillator).
- •Subject has significant arrhythmia.
- •Subject has high grade heart block.
- •Subject has resting heart rate < 45 bpm, systolic blood pressure <90 mm Hg, or has consumed caffeine within the last 12 hours.
- •Subject has an acute psychiatric disorder.
- •Subject is unwilling to comply with the requirements of the protocol.
- •Subject has previously entered this study.
- •Subject has an allergy against iodinated contrast agents or pharmaceutical stressors used in this study.
- •Subject suffers from claustrophobia.
- •Subject has impaired renal function (creatinine > 1.5 mg/dl).
- •Subject is in unstable condition.
- •ST-elevations, new transient ST changes greater than 0.05mV or T- wave inversions with symptoms
- •Subject cannot safely be administered Lexiscan™ per prescribing information as determined by investigator
- •Subject has received interventional (PCI, stenting) or surgical (CABG) treatment that may alter the cardiac condition regarding myocardial perfusion status and/or stenosis degree between cardiac CTA, SPECT, and/or CT stress perfusion studies.
研究组 & 干预措施
Myocardial Stress CT Perfusion
Low-radiation, dynamic perfusion CT of the heart in patients with suspected ischemic chest pain and a moderate or severe stenosis seen on coronary CTA. Lexiscan(TM) will be used as the pharmacological stress agent (coronary vasodilator).
干预措施: Lexiscan (Drug)
结局指标
主要结局
Number of Treatment-related Adverse Events
时间窗: 30 days +/- 3 days
Demonstrate that CTA with stress and rest perfusion imaging using Lexiscan as the coronary vasodilator will be safe and well tolerated. This outcome measure data value represents the number of adverse events that occurred during this study.
次要结局
- Diagnostic Accuracy Using Quantitative Objective Image Quality Assessment(Immediately following CT perfusion imaging.)
研究者
U. Joseph Schoepf, MD
Professor
Medical University of South Carolina