Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; DCOG LATER Q2008 onderzoek: Bone mineral density and body composition in survivors of childhood cancer

Completed

• Conditions: botten, bewegingsapparaat en fitheid; impaired fitness and motor impairment; osteonecrosis; osteoposoris

• Registration Number: NL-OMON47723
• Lead Sponsor: Stichting Kinderoncologie Nederland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 2500

Inclusion Criteria

All patients who were treated for childhood cancer (before age 18) in one of
the Pediatric Oncology Centers between 1960 and 2001 and who survived for at
least 5 years after diagnosis will be included in the DCOG LATER study.
Participating centres are located in Amsterdam (VU University Medical Center
(VUMC)), Groningen (Children's Cancer Center/ University Medical Center
Groningen (UMCG)), Rotterdam (Rotterdam Erasmus MC-Sophia (REMC-S), Nijmegen
(University Medical Center Nijmegen (UMCN)), Leiden (Leiden University Medical
Center (LUMC) and Utrecht (Princess Máxima Center for Pediatric Oncology
(PMC)). From this cohort, 2500 childhood cancer survivors will be asked to
participate in this study. (BMI will be assessed in all 7000 survivors as
regular patient care).

Exclusion Criteria

diagnosis of childhood cancer with survival less than 5 years, age at diagnosis
>17 years or diagnosis while residing in foreign country, no cardiologic
impairment(fitness)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1- Prevalence and exogenous and genetic risk factors of osteopenia and<br /><br>osteoporosis and subsequent fractures, per persons years in CCS. 2- Prevalence<br /><br>of over- and underweight as expressed by BMI and LBM. 3- Treatment and<br /><br>diagnosis related risk factors for irreversible osteonecrosis. 4- Treatment and<br /><br>diagnosis related risk factors for impaired motor function and muscle strength</p><br>

Secondary Outcome Measures

Name	Time	Method
<p><br /><br>N.A.</p><br>