MedPath

Management of Tobacco Treatment Intervention in Reducing Surgical Complications in Patients With Newly Diagnosed Lung Cancer Who Smoke Cigarettes

Phase 3
Terminated
Conditions
Lung Carcinoma
Interventions
Drug: Placebo
Other: Tobacco Cessation Counseling
Registration Number
NCT02856581
Lead Sponsor
Alliance for Clinical Trials in Oncology
Brief Summary

This randomized phase III trial studies how well management of a tobacco treatment intervention works in reducing surgical complications in patients with newly diagnosed lung cancer who smoke cigarettes. Management of a tobacco treatment intervention compares varenicline (a drug that reduces the craving and withdrawal symptoms that occur with abstinence from nicotine) and behavioral interventions (consisting of a brief clinician-delivered intervention and tobacco quitline \[tobacco cessation service available through a toll-free telephone number\] follow-up) with placebo (a pill with no active medication) along with similar behavioral interventions. It is not yet known whether management of a tobacco treatment intervention is more effective in reducing surgical complications than placebo.

Detailed Description

PRIMARY OBJECTIVES:

I. To determine if varenicline plus a behavioral intervention consisting of a brief clinician-delivered intervention and tobacco quitline follow-up, decreases postsurgical complications through 24 weeks after surgery when compared to placebo plus the behavioral intervention in lung cancer patients who undergo surgery and are motivated to stop smoking.

SECONDARY OBJECTIVES:

I. To compare changes from baseline to 12 and 24 weeks after surgery in the patient quality of life (Linear Analogue Self-Assessment \[LASA\]-12) domains between the intervention (varenicline) and control group (placebo).

II. To compare changes from baseline to 6, 12 and 24 weeks after surgery in the patient quality of life related domains (LASA) for the Patient Health Questionnaire (PHQ)-9 and Smoking Self Efficacy Questionnaire (SEQ)12 between the intervention and control groups.

III. To compare the proportion of patients 12 weeks and 24 weeks after surgery who endorse ("Was It Worth It") each treatment (intervention versus \[vs\] control groups).

IV. To compare post-operative care (as measured by length of hospital and high dependency unit stay) between the intervention and control groups.

V. To compare treatment adherence between the intervention and control groups. VI. To compare rates of smoking abstinence between the intervention and control groups as a covariate of the primary outcome only.

Recruitment & Eligibility

Status
TERMINATED
Sex
All
Target Recruitment
23
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Control group (placebo and behavioral intervention)PlaceboPatients receive placebo PO QD on days 1-3 and BID on days 4-84 for 12 weeks in the absence of disease progression or unacceptable toxicity. Patients also complete behavioral intervention consisting of no smoking message from surgical team member and how to use NCI quitline at surgical consult.
Control group (placebo and behavioral intervention)Tobacco Cessation CounselingPatients receive placebo PO QD on days 1-3 and BID on days 4-84 for 12 weeks in the absence of disease progression or unacceptable toxicity. Patients also complete behavioral intervention consisting of no smoking message from surgical team member and how to use NCI quitline at surgical consult.
Intervention group (varenicline and behavioral intervention)Tobacco Cessation CounselingPatients receive varenicline PO QD on days 1-3 and BID on days 4-84 for 12 weeks in the absence of disease progression or unacceptable toxicity. Patients also complete behavioral intervention consisting of no smoking message from surgical team member and how to use NCI quitline at surgical consult.
Intervention group (varenicline and behavioral intervention)VareniclinePatients receive varenicline PO QD on days 1-3 and BID on days 4-84 for 12 weeks in the absence of disease progression or unacceptable toxicity. Patients also complete behavioral intervention consisting of no smoking message from surgical team member and how to use NCI quitline at surgical consult.
Primary Outcome Measures
NameTimeMethod
MortalityUp to 30 days post-surgery

Number of patients that died within 30 days of surgery

Number of Paticipants With Incidence of Pulmonary ComplicationsUp to 24 weeks post-surgery

Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test. Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, Fagerström Test for Nicotine Dependence (FTND), time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy. We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.

Number of Participants With Incidence of Anastomotic FailureUp to 24 weeks post-surgery

Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test. Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, FTND, time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy. A separate logistic model will be created including treatment arm instead of smoking status. We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.

Number of Participants With Incidence of Unspecified Wound InfectionUp to 24 weeks post-surgery

Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test. Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, FTND, time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy. A separate logistic model will be created including treatment arm instead of smoking status. We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.

Re-hospitalizationUp to 30 days post-surgery

Number of patients re-hospitalized within 30 days of surgery

Number of Participants With Incidence of Intensive Care Unit ReadmissionUp to 24 weeks post-surgery

Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test. Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, FTND, time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy. A separate logistic model will be created including treatment arm instead of smoking status. We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.

Secondary Outcome Measures
NameTimeMethod
Change in QOL as Measured by the LASA-12, PHQ-9, SEQ-12Baseline up to 24 weeks after surgery

Analysis of covariance and linear mixed model repeated measures analysis will be used for each assessment domain (LASA-12, PHQ-9, SEQ12).

Expanded Complication RateUp to 1 year
Treatment Adherence Rates Related to Visits, Medication Compliance, Quitline Usage, and Surgeon Teachable Moment DeliveryUp to 12 weeks
Length of Hospital StayThe time from surgery until the patient is released from the hospital

Logrank testing of Kaplan-Meier estimates will be used for length of hospital stay and supplemented by Cox models to control for concomitant covariates.

Change in QOL as Measured by Was It Worth It AssessmentsAt 24 weeks after surgery
Length of High Dependency Unit StayThe time from surgery until the patient is released from the hospital

Logrank testing of Kaplan-Meier estimates will be used for length of high dependency unit stay and supplemented by Cox models to control for concomitant covariates.

Smoking Abstinence Rates as Measured by Self-reportUp to 12 weeks
Smoking Abstinence Rates as Measured by Salivary Cotinine TestingUp to 12 weeks

Trial Locations

Locations (374)

Baptist Health Paducah

🇺🇸

Paducah, Kentucky, United States

Bhadresh Nayak MD PC-Sterling Heights

🇺🇸

Sterling Heights, Michigan, United States

Coborn Cancer Center at Saint Cloud Hospital

🇺🇸

Saint Cloud, Minnesota, United States

Baylor University Medical Center

🇺🇸

Dallas, Texas, United States

Saint Elizabeth Youngstown Hospital

🇺🇸

Youngstown, Ohio, United States

Saint Helena Hospital

🇺🇸

Saint Helena, California, United States

Rocky Mountain Cancer Centers-Boulder

🇺🇸

Boulder, Colorado, United States

Veterans Affairs Loma Linda Healthcare System

🇺🇸

Loma Linda, California, United States

Memorial Hospital North

🇺🇸

Colorado Springs, Colorado, United States

Rocky Mountain Cancer Centers-Littleton

🇺🇸

Littleton, Colorado, United States

Rocky Mountain Cancer Centers-Sky Ridge

🇺🇸

Lone Tree, Colorado, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

🇺🇸

Savannah, Georgia, United States

Memorial Hospital West

🇺🇸

Pembroke Pines, Florida, United States

Boulder Community Hospital

🇺🇸

Boulder, Colorado, United States

North Colorado Medical Center

🇺🇸

Greeley, Colorado, United States

Illinois CancerCare-Canton

🇺🇸

Canton, Illinois, United States

National Jewish Health-Northern Hematology Oncology

🇺🇸

Thornton, Colorado, United States

Summit Cancer Care-Candler

🇺🇸

Savannah, Georgia, United States

Broward Health Medical Center

🇺🇸

Fort Lauderdale, Florida, United States

Illinois CancerCare-Carthage

🇺🇸

Carthage, Illinois, United States

Sky Ridge Medical Center

🇺🇸

Lone Tree, Colorado, United States

Piedmont Hospital

🇺🇸

Atlanta, Georgia, United States

SCL Health Lutheran Medical Center

🇺🇸

Wheat Ridge, Colorado, United States

SIH Cancer Institute

🇺🇸

Carterville, Illinois, United States

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

🇺🇸

Hollywood, Florida, United States

Illinois CancerCare-Ottawa Clinic

🇺🇸

Ottawa, Illinois, United States

Loyola University Medical Center

🇺🇸

Maywood, Illinois, United States

Carle Cancer Center

🇺🇸

Urbana, Illinois, United States

Good Samaritan Medical Center

🇺🇸

Lafayette, Colorado, United States

Carle on Vermilion

🇺🇸

Danville, Illinois, United States

Illinois CancerCare-Kewanee Clinic

🇺🇸

Kewanee, Illinois, United States

Saint Joseph Mercy Chelsea

🇺🇸

Chelsea, Michigan, United States

Memorial Hospital of Carbondale

🇺🇸

Carbondale, Illinois, United States

Carle Physician Group-Mattoon/Charleston

🇺🇸

Mattoon, Illinois, United States

Illinois CancerCare-Pekin

🇺🇸

Pekin, Illinois, United States

IHA Hematology Oncology Consultants-Canton

🇺🇸

Canton, Michigan, United States

Decatur Memorial Hospital

🇺🇸

Decatur, Illinois, United States

Genesee Hematology Oncology PC

🇺🇸

Flint, Michigan, United States

The Carle Foundation Hospital

🇺🇸

Urbana, Illinois, United States

Springfield Clinic

🇺🇸

Springfield, Illinois, United States

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

🇺🇸

Pekin, Illinois, United States

Cancer Care Specialists of Illinois-Swansea

🇺🇸

Swansea, Illinois, United States

Baptist Health Madisonville/Merle Mahr Cancer Center

🇺🇸

Madisonville, Kentucky, United States

Ochsner High Grove

🇺🇸

Baton Rouge, Louisiana, United States

Saint Cloud Hospital

🇺🇸

Saint Cloud, Minnesota, United States

Saint Joseph Mercy Brighton

🇺🇸

Brighton, Michigan, United States

Great Lakes Cancer Management Specialists-Doctors Park

🇺🇸

East China Township, Michigan, United States

Parkland Health Center - Farmington

🇺🇸

Farmington, Missouri, United States

UM Upper Chesapeake Medical Center

🇺🇸

Bel Air, Maryland, United States

IHA Hematology Oncology Consultants-Brighton

🇺🇸

Brighton, Michigan, United States

Saint Elizabeth Boardman Hospital

🇺🇸

Boardman, Ohio, United States

Saint Francis Medical Center

🇺🇸

Cape Girardeau, Missouri, United States

Allegiance Health

🇺🇸

Jackson, Michigan, United States

UP Health System Marquette

🇺🇸

Marquette, Michigan, United States

Saint Mary's Oncology/Hematology Associates of Marlette

🇺🇸

Marlette, Michigan, United States

21st Century Oncology-Pontiac

🇺🇸

Pontiac, Michigan, United States

Huron Medical Center PC

🇺🇸

Port Huron, Michigan, United States

Mayo Clinic Health Systems-Mankato

🇺🇸

Mankato, Minnesota, United States

Sainte Genevieve County Memorial Hospital

🇺🇸

Sainte Genevieve, Missouri, United States

Good Samaritan Hospital - Dayton

🇺🇸

Dayton, Ohio, United States

Vassar Brothers Medical Center

🇺🇸

Poughkeepsie, New York, United States

Aultman Health Foundation

🇺🇸

Canton, Ohio, United States

University of Rochester

🇺🇸

Rochester, New York, United States

Miami Valley Hospital North

🇺🇸

Dayton, Ohio, United States

Thomas Jefferson University Hospital

🇺🇸

Philadelphia, Pennsylvania, United States

Dayton Physicians LLC-Atrium

🇺🇸

Franklin, Ohio, United States

Dayton Physician LLC-Miami Valley Hospital North

🇺🇸

Dayton, Ohio, United States

Orion Cancer Care

🇺🇸

Findlay, Ohio, United States

Dayton Physicians LLC-Miami Valley South

🇺🇸

Centerville, Ohio, United States

Oklahoma Cancer Specialists and Research Institute-Tulsa

🇺🇸

Tulsa, Oklahoma, United States

Dayton Physicians LLC-Wayne

🇺🇸

Greenville, Ohio, United States

Saint Alphonsus Medical Center-Baker City

🇺🇸

Baker City, Oregon, United States

Atrium Medical Center-Middletown Regional Hospital

🇺🇸

Franklin, Ohio, United States

Greater Dayton Cancer Center

🇺🇸

Kettering, Ohio, United States

Mount Nittany Medical Center

🇺🇸

State College, Pennsylvania, United States

Saint Alphonsus Medical Center-Ontario

🇺🇸

Ontario, Oregon, United States

Blanchard Valley Hospital

🇺🇸

Findlay, Ohio, United States

Springfield Regional Medical Center

🇺🇸

Springfield, Ohio, United States

First Dayton Cancer Care

🇺🇸

Kettering, Ohio, United States

Lehigh Valley Hospital-Cedar Crest

🇺🇸

Allentown, Pennsylvania, United States

Geisinger Medical Center

🇺🇸

Danville, Pennsylvania, United States

Prisma Health Cancer Institute - Seneca

🇺🇸

Seneca, South Carolina, United States

Riverton Hospital

🇺🇸

Riverton, Utah, United States

Tacoma/Valley Radiation Oncology Centers-Gig Harbor

🇺🇸

Gig Harbor, Washington, United States

Mayo Clinic Health System-Franciscan Healthcare

🇺🇸

La Crosse, Wisconsin, United States

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Town Center

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada-Summerlin

🇺🇸

Las Vegas, Nevada, United States

Summerlin Hospital Medical Center

🇺🇸

Las Vegas, Nevada, United States

Las Vegas Cancer Center-Medical Center

🇺🇸

Las Vegas, Nevada, United States

21st Century Oncology-Fort Apache

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada

🇺🇸

Las Vegas, Nevada, United States

OptumCare Cancer Care at Fort Apache

🇺🇸

Las Vegas, Nevada, United States

Urology Specialists of Nevada - Southwest

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Central Valley

🇺🇸

Las Vegas, Nevada, United States

University Cancer Center

🇺🇸

Las Vegas, Nevada, United States

Desert West Surgery

🇺🇸

Las Vegas, Nevada, United States

University Medical Center of Southern Nevada

🇺🇸

Las Vegas, Nevada, United States

Hope Cancer Care of Nevada

🇺🇸

Las Vegas, Nevada, United States

Cancer and Blood Specialists-Shadow

🇺🇸

Las Vegas, Nevada, United States

OptumCare Cancer Care at Oakey

🇺🇸

Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Central

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

🇺🇸

Las Vegas, Nevada, United States

Sunrise Hospital and Medical Center

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-San Martin

🇺🇸

Las Vegas, Nevada, United States

Las Vegas Prostate Cancer Center

🇺🇸

Las Vegas, Nevada, United States

Las Vegas Urology - Sunset

🇺🇸

Las Vegas, Nevada, United States

Cancer Therapy and Integrative Medicine

🇺🇸

Las Vegas, Nevada, United States

21st Century Oncology-Vegas Tenaya

🇺🇸

Las Vegas, Nevada, United States

Ann M Wierman MD LTD

🇺🇸

Las Vegas, Nevada, United States

Cancer and Blood Specialists-Tenaya

🇺🇸

Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada - Northwest

🇺🇸

Las Vegas, Nevada, United States

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

🇺🇸

Las Vegas, Nevada, United States

Las Vegas Urology - Cathedral Rock

🇺🇸

Las Vegas, Nevada, United States

Las Vegas Urology - Smoke Ranch

🇺🇸

Las Vegas, Nevada, United States

OptumCare Cancer Care at MountainView

🇺🇸

Las Vegas, Nevada, United States

Urology Specialists of Nevada - Northwest

🇺🇸

Las Vegas, Nevada, United States

Oncology Hematology Care Inc-Kenwood

🇺🇸

Cincinnati, Ohio, United States

University of Mississippi Medical Center

🇺🇸

Jackson, Mississippi, United States

Kingman Regional Medical Center

🇺🇸

Kingman, Arizona, United States

PCR Oncology

🇺🇸

Arroyo Grande, California, United States

Eisenhower Medical Center

🇺🇸

Rancho Mirage, California, United States

UCHealth Memorial Hospital Central

🇺🇸

Colorado Springs, Colorado, United States

Swedish Medical Center

🇺🇸

Englewood, Colorado, United States

Saint Mary's Hospital and Regional Medical Center

🇺🇸

Grand Junction, Colorado, United States

National Jewish Health-Western Hematology Oncology

🇺🇸

Golden, Colorado, United States

McKee Medical Center

🇺🇸

Loveland, Colorado, United States

Indian River Medical Center

🇺🇸

Vero Beach, Florida, United States

Saint Alphonsus Cancer Care Center-Boise

🇺🇸

Boise, Idaho, United States

Kootenai Cancer Center

🇺🇸

Post Falls, Idaho, United States

Northwest Community Hospital

🇺🇸

Arlington Heights, Illinois, United States

Rush - Copley Medical Center

🇺🇸

Aurora, Illinois, United States

Illinois CancerCare-Bloomington

🇺🇸

Bloomington, Illinois, United States

John H Stroger Jr Hospital of Cook County

🇺🇸

Chicago, Illinois, United States

University of Illinois

🇺🇸

Chicago, Illinois, United States

Cancer Care Specialists of Illinois - Decatur

🇺🇸

Decatur, Illinois, United States

Crossroads Cancer Center

🇺🇸

Effingham, Illinois, United States

Eastern Maine Medical Center

🇺🇸

Bangor, Maine, United States

Illinois CancerCare-Dixon

🇺🇸

Dixon, Illinois, United States

Illinois CancerCare-Eureka

🇺🇸

Eureka, Illinois, United States

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

🇺🇸

Melrose Park, Illinois, United States

Illinois CancerCare-Galesburg

🇺🇸

Galesburg, Illinois, United States

Trinity Medical Center

🇺🇸

Moline, Illinois, United States

Western Illinois Cancer Treatment Center

🇺🇸

Galesburg, Illinois, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

🇺🇸

Peoria, Illinois, United States

Methodist Medical Center of Illinois

🇺🇸

Peoria, Illinois, United States

Franciscan Health Indianapolis

🇺🇸

Indianapolis, Indiana, United States

Hematology Oncology Consultants-Clarkston

🇺🇸

Clarkston, Michigan, United States

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

🇺🇸

Grosse Pointe Woods, Michigan, United States

Academic Hematology Oncology Specialists

🇺🇸

Grosse Pointe Woods, Michigan, United States

UP Health System Hematology Oncology Marquette

🇺🇸

Marquette, Michigan, United States

Hope Cancer Center

🇺🇸

Pontiac, Michigan, United States

Oncology Hematology Associates of Saginaw Valley PC

🇺🇸

Saginaw, Michigan, United States

Macomb Hematology Oncology PC

🇺🇸

Warren, Michigan, United States

Parkland Health Center-Bonne Terre

🇺🇸

Bonne Terre, Missouri, United States

Las Vegas Urology - Green Valley

🇺🇸

Henderson, Nevada, United States

21st Century Oncology

🇺🇸

Las Vegas, Nevada, United States

Urology Specialists of Nevada - Central

🇺🇸

Las Vegas, Nevada, United States

Radiation Oncology Centers of Nevada Southeast

🇺🇸

Las Vegas, Nevada, United States

Saint Mary's Regional Medical Center

🇺🇸

Reno, Nevada, United States

Alliance Cancer Center

🇺🇸

Alliance, Ohio, United States

Indu and Raj Soin Medical Center

🇺🇸

Beavercreek, Ohio, United States

Miami Valley Hospital South

🇺🇸

Centerville, Ohio, United States

Springfield Regional Cancer Center

🇺🇸

Springfield, Ohio, United States

Saint Joseph Warren Hospital

🇺🇸

Warren, Ohio, United States

Upper Valley Medical Center

🇺🇸

Troy, Ohio, United States

Geisinger Medical Oncology-Lewisburg

🇺🇸

Lewisburg, Pennsylvania, United States

Geisinger Medical Center-Cancer Center Hazleton

🇺🇸

Hazleton, Pennsylvania, United States

Lehigh Valley Hospital-Hazleton

🇺🇸

Hazleton, Pennsylvania, United States

Fox Chase Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

Community Medical Center

🇺🇸

Scranton, Pennsylvania, United States

Geisinger Medical Oncology-Selinsgrove

🇺🇸

Selinsgrove, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center

🇺🇸

Wilkes-Barre, Pennsylvania, United States

Prisma Health Cancer Institute - Laurens

🇺🇸

Clinton, South Carolina, United States

Prisma Health Cancer Institute - Easley

🇺🇸

Easley, South Carolina, United States

Prisma Health Cancer Institute - Butternut

🇺🇸

Greenville, South Carolina, United States

Prisma Health Cancer Institute - Faris

🇺🇸

Greenville, South Carolina, United States

Prisma Health Greenville Memorial Hospital

🇺🇸

Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside

🇺🇸

Greenville, South Carolina, United States

Baptist Memorial Hospital and Cancer Center-Memphis

🇺🇸

Memphis, Tennessee, United States

UTMB Cancer Center at Victory Lakes

🇺🇸

League City, Texas, United States

University of Texas Medical Branch

🇺🇸

Galveston, Texas, United States

American Fork Hospital / Huntsman Intermountain Cancer Center

🇺🇸

American Fork, Utah, United States

Sandra L Maxwell Cancer Center

🇺🇸

Cedar City, Utah, United States

Logan Regional Hospital

🇺🇸

Logan, Utah, United States

Intermountain Medical Center

🇺🇸

Murray, Utah, United States

McKay-Dee Hospital Center

🇺🇸

Ogden, Utah, United States

Utah Valley Regional Medical Center

🇺🇸

Provo, Utah, United States

LDS Hospital

🇺🇸

Salt Lake City, Utah, United States

Utah Cancer Specialists-Salt Lake City

🇺🇸

Salt Lake City, Utah, United States

University of Vermont Medical Center

🇺🇸

Burlington, Vermont, United States

Sentara Martha Jefferson Hospital

🇺🇸

Charlottesville, Virginia, United States

University of Vermont and State Agricultural College

🇺🇸

Burlington, Vermont, United States

University of Virginia Cancer Center

🇺🇸

Charlottesville, Virginia, United States

Augusta Health Center for Cancer and Blood Disorders

🇺🇸

Fishersville, Virginia, United States

Sentara Norfolk General Hospital

🇺🇸

Norfolk, Virginia, United States

MultiCare Auburn Medical Center

🇺🇸

Auburn, Washington, United States

Virginia Mason Bainbridge Island Medical Center

🇺🇸

Bainbridge Island, Washington, United States

Overlake Hospital Medical Center

🇺🇸

Bellevue, Washington, United States

Virginia Mason Federal Way Medical Center

🇺🇸

Federal Way, Washington, United States

MultiCare Gig Harbor Medical Park

🇺🇸

Gig Harbor, Washington, United States

Northwest Cancer Clinic

🇺🇸

Kennewick, Washington, United States

Virginia Mason Lynnwood Medical Center

🇺🇸

Lynnwood, Washington, United States

Jefferson Healthcare

🇺🇸

Port Townsend, Washington, United States

Peninsula Cancer Center

🇺🇸

Poulsbo, Washington, United States

MultiCare Good Samaritan Hospital

🇺🇸

Puyallup, Washington, United States

Virginia Mason Medical Center

🇺🇸

Seattle, Washington, United States

Valley Medical Center

🇺🇸

Renton, Washington, United States

Tacoma/Valley Radiation Oncology Centers-Puyallup

🇺🇸

Puyallup, Washington, United States

Rockwood Clinic Cancer Treatment Center-Valley

🇺🇸

Spokane Valley, Washington, United States

Rockwood Cancer Treatment Center-DHEC-Downtown

🇺🇸

Spokane, Washington, United States

Rockwood North Cancer Treatment Center

🇺🇸

Spokane, Washington, United States

Mary Bridge Children's Hospital and Health Center

🇺🇸

Tacoma, Washington, United States

MultiCare Tacoma General Hospital

🇺🇸

Tacoma, Washington, United States

Tacoma/Valley Radiation Oncology Centers-Saint Joe's

🇺🇸

Tacoma, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

🇺🇸

Yakima, Washington, United States

Billings Clinic-Cody

🇺🇸

Cody, Wyoming, United States

Cheyenne Regional Medical Center-West

🇺🇸

Cheyenne, Wyoming, United States

Welch Cancer Center

🇺🇸

Sheridan, Wyoming, United States

Dixie Medical Center Regional Cancer Center

🇺🇸

Saint George, Utah, United States

Missouri Baptist Sullivan Hospital

🇺🇸

Sullivan, Missouri, United States

Missouri Baptist Outpatient Center-Sunset Hills

🇺🇸

Sunset Hills, Missouri, United States

Missouri Baptist Medical Center

🇺🇸

Saint Louis, Missouri, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

🇺🇸

New York, New York, United States

Mountain Blue Cancer Care Center - Swedish

🇺🇸

Englewood, Colorado, United States

Saint James Community Hospital and Cancer Treatment Center

🇺🇸

Butte, Montana, United States

East Carolina University

🇺🇸

Greenville, North Carolina, United States

Centralia Oncology Clinic

🇺🇸

Centralia, Illinois, United States

Illinois CancerCare-Macomb

🇺🇸

Macomb, Illinois, United States

Carle Physician Group-Effingham

🇺🇸

Effingham, Illinois, United States

Chancellor Center for Oncology

🇺🇸

Newburgh, Indiana, United States

Illinois CancerCare-Peoria

🇺🇸

Peoria, Illinois, United States

OSF Saint Francis Medical Center

🇺🇸

Peoria, Illinois, United States

Baptist Health Corbin

🇺🇸

Corbin, Kentucky, United States

Illinois CancerCare-Princeton

🇺🇸

Princeton, Illinois, United States

Southwest Illinois Health Services LLP

🇺🇸

Swansea, Illinois, United States

Rush-Copley Healthcare Center

🇺🇸

Yorkville, Illinois, United States

Deaconess Clinic Downtown

🇺🇸

Evansville, Indiana, United States

Parkview Hospital Randallia

🇺🇸

Fort Wayne, Indiana, United States

Memorial Regional Cancer Center Day Road

🇺🇸

Mishawaka, Indiana, United States

Franciscan Health Mooresville

🇺🇸

Mooresville, Indiana, United States

Reid Health

🇺🇸

Richmond, Indiana, United States

Memorial Hospital of South Bend

🇺🇸

South Bend, Indiana, United States

Mercy Medical Center

🇺🇸

Springfield, Massachusetts, United States

Miami Valley Hospital

🇺🇸

Dayton, Ohio, United States

Wayne Hospital

🇺🇸

Greenville, Ohio, United States

Dayton Physicians LLC-Upper Valley

🇺🇸

Troy, Ohio, United States

Lehigh Valley Hospital - Muhlenberg

🇺🇸

Bethlehem, Pennsylvania, United States

Pocono Medical Center

🇺🇸

East Stroudsburg, Pennsylvania, United States

Lewistown Hospital

🇺🇸

Lewistown, Pennsylvania, United States

Geisinger Medical Group

🇺🇸

State College, Pennsylvania, United States

Geisinger Cancer Services-Pottsville

🇺🇸

Pottsville, Pennsylvania, United States

Saint Joseph Mercy Canton

🇺🇸

Canton, Michigan, United States

IHA Hematology Oncology Consultants-Chelsea

🇺🇸

Chelsea, Michigan, United States

Caro Cancer Center

🇺🇸

Caro, Michigan, United States

Genesee Cancer and Blood Disease Treatment Center

🇺🇸

Flint, Michigan, United States

Genesys Hurley Cancer Institute

🇺🇸

Flint, Michigan, United States

Hurley Medical Center

🇺🇸

Flint, Michigan, United States

Michigan Breast Specialists-Grosse Pointe Woods

🇺🇸

Grosse Pointe Woods, Michigan, United States

Ascension Saint Joseph Hospital

🇺🇸

Tawas City, Michigan, United States

Hope Cancer Clinic

🇺🇸

Livonia, Michigan, United States

Sparrow Hospital

🇺🇸

Lansing, Michigan, United States

Lake Huron Medical Center

🇺🇸

Port Huron, Michigan, United States

Saint Mary Mercy Hospital

🇺🇸

Livonia, Michigan, United States

Great Lakes Cancer Management Specialists-Macomb Medical Campus

🇺🇸

Macomb, Michigan, United States

Ascension Saint Mary's Hospital

🇺🇸

Saginaw, Michigan, United States

Great Lakes Cancer Management Specialists-Rochester Hills

🇺🇸

Rochester Hills, Michigan, United States

Michigan Breast Specialists-Warren

🇺🇸

Warren, Michigan, United States

Saint John Macomb-Oakland Hospital

🇺🇸

Warren, Michigan, United States

Saint Mary's Oncology/Hematology Associates of West Branch

🇺🇸

West Branch, Michigan, United States

Huron Gastroenterology PC

🇺🇸

Ypsilanti, Michigan, United States

IHA Hematology Oncology Consultants-Ann Arbor

🇺🇸

Ypsilanti, Michigan, United States

Parkview Regional Medical Center

🇺🇸

Fort Wayne, Indiana, United States

Valley Radiation Oncology

🇺🇸

Peru, Illinois, United States

Illinois CancerCare-Peru

🇺🇸

Peru, Illinois, United States

Beaumont Hospital - Dearborn

🇺🇸

Dearborn, Michigan, United States

Woodland Cancer Care Center

🇺🇸

Michigan City, Indiana, United States

Memorial Medical Center

🇺🇸

Springfield, Illinois, United States

Newland Medical Associates-Clarkston

🇺🇸

Clarkston, Michigan, United States

Southern Illinois University School of Medicine

🇺🇸

Springfield, Illinois, United States

Lafayette Family Cancer Center-EMMC

🇺🇸

Brewer, Maine, United States

Advanced Breast Care Center PLLC

🇺🇸

Warren, Michigan, United States

Saint Joseph Mercy Oakland

🇺🇸

Pontiac, Michigan, United States

Michigan Breast Specialists-Macomb Township

🇺🇸

Macomb, Michigan, United States

Newland Medical Associates-Pontiac

🇺🇸

Pontiac, Michigan, United States

Great Lakes Cancer Management Specialists-Macomb Professional Building

🇺🇸

Warren, Michigan, United States

Kettering Medical Center

🇺🇸

Kettering, Ohio, United States

Rocky Mountain Cancer Centers-Aurora

🇺🇸

Aurora, Colorado, United States

The Medical Center of Aurora

🇺🇸

Aurora, Colorado, United States

University of Colorado Hospital

🇺🇸

Aurora, Colorado, United States

Cancer Center of Colorado at Sloan's Lake

🇺🇸

Denver, Colorado, United States

National Jewish Health-Main Campus

🇺🇸

Denver, Colorado, United States

The Women's Imaging Center

🇺🇸

Denver, Colorado, United States

Colorado Blood Cancer Institute

🇺🇸

Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One

🇺🇸

Denver, Colorado, United States

Western Surgical Care

🇺🇸

Denver, Colorado, United States

University of Michigan Comprehensive Cancer Center

🇺🇸

Ann Arbor, Michigan, United States

Ascension Saint John Hospital

🇺🇸

Detroit, Michigan, United States

Rocky Mountain Cancer Centers-Midtown

🇺🇸

Denver, Colorado, United States

SCL Health Saint Joseph Hospital

🇺🇸

Denver, Colorado, United States

Rocky Mountain Cancer Centers-Rose

🇺🇸

Denver, Colorado, United States

Rose Medical Center

🇺🇸

Denver, Colorado, United States

Saint Joseph Mercy Hospital

🇺🇸

Ann Arbor, Michigan, United States

Mayo Clinic

🇺🇸

Rochester, Minnesota, United States

Nebraska Methodist Hospital

🇺🇸

Omaha, Nebraska, United States

University of Oklahoma Health Sciences Center

🇺🇸

Oklahoma City, Oklahoma, United States

Aurora Saint Luke's Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Comprehensive Cancer Centers of Nevada - Henderson

🇺🇸

Henderson, Nevada, United States

21st Century Oncology-Henderson

🇺🇸

Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada-Southeast Henderson

🇺🇸

Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada-Horizon Ridge

🇺🇸

Henderson, Nevada, United States

OptumCare Cancer Care at Seven Hills

🇺🇸

Henderson, Nevada, United States

Las Vegas Cancer Center-Henderson

🇺🇸

Henderson, Nevada, United States

Las Vegas Urology - Pebble

🇺🇸

Henderson, Nevada, United States

Urology Specialists of Nevada - Green Valley

🇺🇸

Henderson, Nevada, United States

Baptist Health Louisville

🇺🇸

Louisville, Kentucky, United States

Ralph H Johnson VA Medical Center

🇺🇸

Charleston, South Carolina, United States

Kootenai Cancer Clinic

🇺🇸

Sandpoint, Idaho, United States

Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

🇺🇸

Jonesboro, Arkansas, United States

Fairbanks Memorial Hospital

🇺🇸

Fairbanks, Alaska, United States

Saint Alphonsus Medical Center-Nampa

🇺🇸

Nampa, Idaho, United States

Idaho Urologic Institute-Meridian

🇺🇸

Meridian, Idaho, United States

Veterans Affairs Connecticut Healthcare System-West Haven Campus

🇺🇸

West Haven, Connecticut, United States

Kootenai Medical Center

🇺🇸

Coeur d'Alene, Idaho, United States

Middlesex Hospital

🇺🇸

Middletown, Connecticut, United States

Saint Alphonsus Cancer Care Center-Caldwell

🇺🇸

Caldwell, Idaho, United States

Walter Knox Memorial Hospital

🇺🇸

Emmett, Idaho, United States

Mary Bird Perkins Cancer Center

🇺🇸

Baton Rouge, Louisiana, United States

Medical Center of Baton Rouge

🇺🇸

Baton Rouge, Louisiana, United States

Baptist Memorial Hospital and Cancer Center-Golden Triangle

🇺🇸

Columbus, Mississippi, United States

Baptist Memorial Hospital and Cancer Center-Union County

🇺🇸

New Albany, Mississippi, United States

Saint Peter's Community Hospital

🇺🇸

Helena, Montana, United States

Bozeman Deaconess Hospital

🇺🇸

Bozeman, Montana, United States

Community Hospital of Anaconda

🇺🇸

Anaconda, Montana, United States

Cancer and Blood Specialists-Henderson

🇺🇸

Henderson, Nevada, United States

Benefis Healthcare- Sletten Cancer Institute

🇺🇸

Great Falls, Montana, United States

Great Falls Clinic

🇺🇸

Great Falls, Montana, United States

Kalispell Regional Medical Center

🇺🇸

Kalispell, Montana, United States

Community Medical Hospital

🇺🇸

Missoula, Montana, United States

Carson Tahoe Regional Medical Center

🇺🇸

Carson City, Nevada, United States

Las Vegas Urology - Pecos

🇺🇸

Las Vegas, Nevada, United States

Hunterdon Medical Center

🇺🇸

Flemington, New Jersey, United States

Hope Cancer Care of Nevada-Pahrump

🇺🇸

Pahrump, Nevada, United States

Renown Regional Medical Center

🇺🇸

Reno, Nevada, United States

Radiation Oncology Associates

🇺🇸

Reno, Nevada, United States

Prisma Health Cancer Institute - Spartanburg

🇺🇸

Spartanburg, South Carolina, United States

Ocean Medical Center

🇺🇸

Brick, New Jersey, United States

Dartmouth Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

Southern Ocean County Medical Center

🇺🇸

Manahawkin, New Jersey, United States

The Cancer Institute of New Jersey Hamilton

🇺🇸

Hamilton, New Jersey, United States

Bayshore Community Hospital

🇺🇸

Holmdel, New Jersey, United States

Jersey Shore Medical Center

🇺🇸

Neptune, New Jersey, United States

Riverview Medical Center/Booker Cancer Center

🇺🇸

Red Bank, New Jersey, United States

Virtua Voorhees

🇺🇸

Voorhees, New Jersey, United States

Baptist Memorial Hospital for Women

🇺🇸

Memphis, Tennessee, United States

Prisma Health Cancer Institute - Greer

🇺🇸

Greer, South Carolina, United States

Central Vermont Medical Center/National Life Cancer Treatment

🇺🇸

Berlin, Vermont, United States

University of Florida Health Science Center - Gainesville

🇺🇸

Gainesville, Florida, United States

Baptist Health Lexington

🇺🇸

Lexington, Kentucky, United States

Ochsner Medical Center Jefferson

🇺🇸

New Orleans, Louisiana, United States

Tacoma/Valley Radiation Oncology Centers-Jackson Hall

🇺🇸

Tacoma, Washington, United States

Billings Clinic Cancer Center

🇺🇸

Billings, Montana, United States

Saint Vincent Healthcare

🇺🇸

Billings, Montana, United States

Saint Vincent Frontier Cancer Center

🇺🇸

Billings, Montana, United States

Southeast Cancer Center

🇺🇸

Cape Girardeau, Missouri, United States

Armes Family Cancer Center

🇺🇸

Findlay, Ohio, United States

Capital Region Southwest Campus

🇺🇸

Jefferson City, Missouri, United States

Baptist Memorial Hospital and Cancer Center-Desoto

🇺🇸

Southhaven, Mississippi, United States

Robert Wood Johnson University Hospital Somerset

🇺🇸

Somerville, New Jersey, United States

Singing River Hospital

🇺🇸

Pascagoula, Mississippi, United States

Glens Falls Hospital

🇺🇸

Glens Falls, New York, United States

Baptist Memorial Hospital and Cancer Center-Oxford

🇺🇸

Oxford, Mississippi, United States

Virtua Memorial

🇺🇸

Mount Holly, New Jersey, United States

© Copyright 2025. All Rights Reserved by MedPath