Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures
- Conditions
- Obesity
- Interventions
- Other: standard test meal
- Registration Number
- NCT02160379
- Lead Sponsor
- University of Lausanne
- Brief Summary
This is a cross-sectional study enrolling
* 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)
* 11 age- and weight-matched female subjects
* 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal
* electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures
* plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are
* to evaluate the effects of RYGB on brain perception of food related visual stimulation
* to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 31
- good apparent health
- gender: female
- age 18-50
- non-smoker
- diabetes or antidiabetic medication
- consumption of more than 50g alcohol per week
- vegetarian or any special diet
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description post Roux-en-Y-gastric bypass standard test meal Formerly obese females 1-5 years after gastric bypass matched controls standard test meal non-operated females age-and weight-matched to post Roux-en-Y-gastric bypass subjects healthy young controls standard test meal non overweight (BMI between 19 and 25 kg/m2) healthy females
- Primary Outcome Measures
Name Time Method Changes of visually-evoked EEG potentials after ingestion of a meal basal, 120 min postprandial and 240 postprandial Recording and analysis of visual evoked potentials (VEPs) while patients categorize photographs of foods and non-food kitchen utensils
- Secondary Outcome Measures
Name Time Method changes in plasma glucoregulatory status after ingestion of a meal basal, 90 min postprandial and 180 postprandial Measurement of glucose, insulin, glucagon and non-esterified fatty acid concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)
changes in plasma triglyceride concentration after ingestion of a meal basal, 90 min postprandial and 180 postprandial Measurement of triglyceride concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)
Changes in plasma glucoincretins (GLP1 and GIP) concentrations after ingestion of a meal basal, 90 min postprandial and 180 postprandial Measurement of GLP1 and GIP concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)
Changes in plasma cholecystokinin concentrations after ingestion of a meal basal, 90 min postprandial and 180 postprandial Measurement of cholecystokinin concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)
Changes in plasma bile acids concentrations after ingestion of a meal basal, 90 min postprandial and 180 postprandial Measurement of bile acids concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)
Trial Locations
- Locations (1)
CHUV-clinical research center
🇨🇭Lausanne, VD, Switzerland