A Randomized Clinical Trial Comparing Computer-assisted Cognitive Rehabilitation (CACR), Psycho-stimulants, and Placebo CACR in the Treatment of Attention Deficit/ Hyperactivity Disorder
Overview
- Phase
- Phase 3
- Intervention
- Computerized cognitive rehabilitation
- Conditions
- Attention Deficit Disorder With Hyperactivity
- Sponsor
- Allameh Tabatabai University
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Forward/Reversed digit span tasks from the WISC-R testing battery.
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Current research aimed to compare the efficacy of computer-assisted cognitive rehabilitation (CACR), stimulant drugs and Placebo CACR on executive functions and clinical symptoms of children with attention deficit/hyperactivity disorder (ADHD).
Detailed Description
The investigators administered a randomized controlled trial (RCT) through random assignment of ADHD subjects in to three different groups to compare the effects of CACR, immediate-release methylphenidate, and a Placebo CACR (i.e. some computerized tasks assumed not having any therapeutic effects) on the functioning of children with ADHD.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ADHD diagnosis
- •age between 7 and 12
Exclusion Criteria
- •sever co-morbid disorder
- •disability
- •sever medical condition
Arms & Interventions
Computerized cognitive rehabilitation
-Computer-assisted cognitive rehabilitation (CACR): 20 Ninety-minute sessions of CACR.
Intervention: Computerized cognitive rehabilitation
Placebo CACR [PCACR]
-PCACR group simultaneously received 20 Ninety-minute sessions of Placebo CACR.
Intervention: Placebo CACR [PCACR]
Ritalin
-2 to 3 doses of 10 mg Ritalin tablets per day during two months.
Intervention: Ritalin
Outcomes
Primary Outcomes
Forward/Reversed digit span tasks from the WISC-R testing battery.
Time Frame: 5 months
Reversed digit span from the WISC-R (Wechsler, 1974) was used to measure executive verbal WM and the forward digit span was used to measure short-term memory.
Raven's colored progressive matrices.
Time Frame: 5 months
Raven's colored progressive matrices (Raven, 1995) was used to measure complex non-verbal reasoning.
Persian software for the continuous performance test [CPT]
Time Frame: 5 months
The Persian software of CPT is a visual CPT test.
Persian software for the Tower of London Test [TOL]
Time Frame: 5 months
Persian TOL is a software version of tower of London test (TOL) which was developed in Iran.
Span board task from the Lumosity.com online software (Lumosity.com, 2012)
Time Frame: 5 months
SNAP-IV scales
Time Frame: 5 months