To Compare The Dose Of Propofol Drug For Induction Of General Anaesthesia As Determined By Entropy Monitoring Against The Standard Induction Dose In Elderly Patients

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/01/048808
• Lead Sponsor: Not applicable

Brief Summary

Propofol is the most common intravenous anaesthetic agent used for induction of general Anesthesia.Standard practice is always cautious and anesthestist always tend to give larger doses than the required to avoid awareness which is terrific.As age increases there is reduced hepatic blood flow and reduction in liver mass which decreases the clearance of propofol and increases the risk of cardiovascular adverse effects such as hypotension.Entropy monitoring is method to analyse depth of Anesthesia done by hypnotic drugs through EEG ,EMG.It has two parameters ,RE (response entropy)which includes EEG and EMG.SE(state entropy) includes EEG .Target range for adequate depth is 40 to 60band difference between RE and SE is less than 10.So by giving propofol based on entropy monitoring will not only avoid giving excessive deepening of Anesthesia.So giving propofol during induction of general Anesthesia based on entropy is a useful tool to give adequate depth and maintaining haemodynamic stability of elderly patients.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-01-16
• Study Start: 2023-09-01

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

Adult patients in age group more than 50 years of either sex belonging to American Society of Anesthesiologist 1&2.

Exclusion Criteria

1.Patients who have history of allergy to propfol.2.patients with history of cardiac disease.3.ASA 3 and ASA 4 STATUS patients.4.long term use of drugs affecting the central nervous system.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To know whether there is decrease in requirements of propofol during induction of general Anesthesia in elderly patients.	4 weeks

Secondary Outcome Measures

Name	Time	Method
To know the haemodynamic stability of the patients	To record systolic Blood pressure,diastolic blood pressure,mean blood pressure,heart rate at baseline,after induction.after intubation at 1 minute.

Trial Locations

Locations (1)

Seth GS medical college and kem hospital; 🇮🇳 (Suburban), MAHARASHTRA, India

Seth GS medical college and kem hospital

🇮🇳(Suburban), MAHARASHTRA, India

Madhavi Buddhi

Principal investigator

9082113320

syama35@gmail.com