Cognitive Fraility and Biomarkers in Older Patients

Completed

• Conditions: Cognitive Impairment; Frail Older Adults; Orthopaedic Surgery

• Registration Number: NCT07184073
• Lead Sponsor: Baskent University

Brief Summary

this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery.

The main questions it aims to answer is:

* Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions?

* Can these biomarkers be used as potential tools for early identification in vulnarable populations?

Detailed Description

It is a cross sectional study

Study Timeline

• Study Start: 2021-06-03
• Primary Completion: 2022-09-04
• Study Completion: 2022-09-04
• Status Verified: 2025-09
• Study First Submitted: 2025-09-13
• Study First Submitted QC: 2025-09-13
• Last Update Submitted: 2025-09-13
• Study First Posted: 2025-09-19
• Last Update Posted: 2025-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 129

Inclusion Criteria

• ASA 1-3 patients
• >65 age patients

Exclusion Criteria

• history of psychiatric or neurological disease
• uncontrolled hypertension
• alchohol dependence
• renal failure
• active liver disease
• cancer-related or emergency surgery
• unwillingness to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function?	preoperatively and four weeks postoperatively	p\<0,05 was accepted as statistically significant

Trial Locations

Locations (1)

Baskent University Ankara Hospital; Ankara, Turkey (Türkiye)