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Injection of Lymphocytes From Haplo-identical Donor Following Chemotherapy in Patients With High-risk Acute Myeloblastic Leukemia Not Eligible for an Allogeneic Hematopoietic Stem Cell Transplantation

Phase 1
Recruiting
Conditions
Acute Myeloid Leukemia (AML)
First Posted Date
2021-05-13
Last Posted Date
2022-05-11
Lead Sponsor
Nantes University Hospital
Target Recruit Count
12
Registration Number
NCT04886206
Locations
🇫🇷

CHU de Nantes, Nantes, France

A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant

Phase 2
Active, not recruiting
Conditions
Acute Myeloid Leukemia (AML)
Acute Lymphoid Leukemia (ALL)
Myelodysplastic Syndromes (MDS)
Interventions
Other: Personalized rATG (P-rATG)
Radiation: Hyper fractionated total body irradiation
Drug: GCSF
First Posted Date
2021-05-04
Last Posted Date
2025-09-04
Lead Sponsor
Memorial Sloan Kettering Cancer Center
Target Recruit Count
59
Registration Number
NCT04872595
Locations
🇺🇸

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Study of Oral Venetoclax Tablets to Evaluate Adverse Events and Change in Disease Activity in Participants Above 19 Years of Age With Acute Myeloid Leukemia (AML)

Recruiting
Conditions
Acute Myeloid Leukemia (AML)
First Posted Date
2021-04-01
Last Posted Date
2025-07-16
Lead Sponsor
AbbVie
Target Recruit Count
600
Registration Number
NCT04826523
Locations
🇰🇷

Pusan National University Hospital /ID# 239010, Busan, Busan Gwang Yeogsi, Korea, Republic of

🇰🇷

Kosin University Gospel Hospital /ID# 257399, Busan, Busan Gwang Yeogsi, Korea, Republic of

🇰🇷

Kyungpook National University Hospital /ID# 257398, Daegu, Daegu Gwang Yeogsi, Korea, Republic of

and more 7 locations

A Clinical Trial to Evaluate Clifutinib in Patients With Relapsed or Refractory Acute Myeloid Leukemia(AML)

Phase 1
Conditions
Acute Myeloid Leukemia
Interventions
First Posted Date
2021-04-01
Last Posted Date
2022-08-12
Lead Sponsor
Sunshine Lake Pharma Co., Ltd.
Target Recruit Count
80
Registration Number
NCT04827069
Locations
🇨🇳

the First Affiliated Hospital,College of Medicine,Zhejiang University, Hanzhou, China

GEN3014 Trial in Relapsed or Refractory Hematologic Malignancies

Phase 1
Completed
Conditions
Relapsed or Refractory Multiple Myeloma (RRMM)
Diffuse Large B Cell Lymphoma (DLBCL)
Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2021-04-01
Last Posted Date
2025-09-03
Lead Sponsor
Genmab
Target Recruit Count
130
Registration Number
NCT04824794
Locations
🇺🇸

John Theurer Cancer Center, Hackensack, New Jersey, United States

🇺🇸

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States

🇺🇸

Medical college of Wisconsin, Milwaukee, Wisconsin, United States

and more 49 locations

Study of Oral Venetoclax Tablets to Evaluate Adverse Events and Change in Disease Activity in Participants of Any Age With Acute Myeloid Leukemia

Completed
Conditions
Acute Myeloid Leukemia (AML)
First Posted Date
2021-03-24
Last Posted Date
2025-04-27
Lead Sponsor
AbbVie
Target Recruit Count
424
Registration Number
NCT04813263
Locations
🇯🇵

Anjou Kousei Hospital /ID# 244213, Anjo-shi, Aichi, Japan

🇯🇵

Nagoya City University Hospital /ID# 256177, Nagoya shi, Aichi, Japan

🇯🇵

Nagoya City West Medical Center /ID# 250844, Nagoya-shi, Aichi, Japan

and more 278 locations

Prospective Non-interventional Study of Adult Patients With Acute Myeloid Leukemia (AML)

Recruiting
Conditions
Acute Myeloid Leukemia (AML)
First Posted Date
2021-03-02
Last Posted Date
2024-01-31
Lead Sponsor
Acute Leukemia French Association
Target Recruit Count
2500
Registration Number
NCT04777916
Locations
🇫🇷

Chu Amiens, Amiens, France

🇫🇷

Centre Hospitalier Victor Dupouy, Argenteuil, France

🇫🇷

AP-HP-GHU - Hôpital AVICENNE, Bobigny, France

and more 27 locations

A Study of SKLB1028 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory (R/R) AML With FLT3-Mutated

Phase 3
Recruiting
Conditions
Acute Myeloid Leukemia (AML)
Interventions
Drug: Salvage Chemotherapy
First Posted Date
2021-01-20
Last Posted Date
2021-11-02
Lead Sponsor
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Target Recruit Count
315
Registration Number
NCT04716114
Locations
🇨🇳

West China hospital of Sichuan University, Chengdu, Sichuan, China

VOB560-MIK665 Combination First in Human Trial in Patients With Hematological Malignancies (Relapsed/Refractory Non-Hodgkin Lymphoma, Relapsed/Refractory Acute Myeloid Leukemia, or Relapsed/Refractory Multiple Myeloma)

Phase 1
Terminated
Conditions
Non-Hodgkin Lymphoma (NHL)
Acute Myeloid Leukemia (AML)
Multiple Myeloma (MM)
Interventions
First Posted Date
2021-01-08
Last Posted Date
2025-06-25
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
37
Registration Number
NCT04702425
Locations
🇺🇸

Uni of TX MD Anderson Cancer Cntr UT MD Anderson Cancer Ctr, Houston, Texas, United States

🇪🇸

Novartis Investigative Site, Santander, Cantabria, Spain

A Study to Assess the Safety of Xospata in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-Like Tyrosine Kinase 3 (FLT3) Mutation

Completed
Conditions
Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation
Interventions
First Posted Date
2020-12-31
Last Posted Date
2025-05-31
Lead Sponsor
Astellas Pharma Korea, Inc.
Target Recruit Count
33
Registration Number
NCT04691648
Locations
🇰🇷

Site KR82013, Wonju-si, Gangwon-do, Korea, Republic of

🇰🇷

Site KR82006, Goyang-si, Gyeonggi-do, Korea, Republic of

🇰🇷

Site KR82003, Jeollanam-do, Hwasun-gun, Korea, Republic of

and more 7 locations

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