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An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa

Phase 2

Terminated

Conditions: Retinitis Pigmentosa
Usher Syndrome Type 2

Interventions: Drug: RNA antisense oligonucleotide for intravitreal injection

First Posted Date: 2021-10-20

Last Posted Date: 2024-08-07

Lead Sponsor: Laboratoires Thea

Target Recruit Count: 21

Registration Number: NCT05085964

Locations: 🇺🇸
Retina Foundation of the Southwest, Dallas, Texas, United States
🇺🇸
University of Michigan, Kellogg Eye Center, Ann Arbor, Michigan, United States
🇺🇸
Center for Clinical Research Operations, Massachusetts Eye and Ear, Boston, Massachusetts, United States

and more 4 locations

Evaluation of Renal Damage After PCNL and ESWL Using Novel RNA Based Biomarkers

Not Applicable

Conditions: Percutaneous Nephrolithotomy
Acute Kidney Injury
Renal Calculi
Extracorporeal Shockwave Lithotripsy

Interventions: Procedure: Extracorporeal Shock Wave Lithotripsy
Procedure: Percutaneous nephrolithotomy

First Posted Date: 2021-10-13

Last Posted Date: 2022-02-22

Lead Sponsor: Ain Shams University

Target Recruit Count: 75

Registration Number: NCT05077007

Locations: 🇪🇬
Urology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Efficacy and Safety of Heterologous and Homologous COVID-19 Vaccination

Not Applicable

Completed

Conditions: Healthy Adult Volunteers

Interventions: Biological: ChAdOx1-nCov-19 (Astra-Zeneca)
Biological: SARS-CoV-2 messenger RNA-1273 (Moderna) vaccine

First Posted Date: 2021-10-12

Last Posted Date: 2022-10-18

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 499

Registration Number: NCT05074368

Locations: 🇨🇳
National Taiwan University Hospital, Taipei City, X, Taiwan

Study of Interferon-Gamma in the Complex Treatment of Patients Infected With HIV and Tuberculosis

Phase 1

Completed

Conditions: Aids/Hiv Problem
Human Immunodeficiency Virus
Lentivirus Infections
HIV Coinfection
Tuberculosis, Pulmonary
RNA Virus Infections

Interventions: Drug: Interferon-Gamma

First Posted Date: 2021-10-04

Last Posted Date: 2024-01-25

Lead Sponsor: SPP Pharmaclon Ltd.

Target Recruit Count: 78

Registration Number: NCT05065905

Locations: 🇷🇺
Saint-Petersburg State Medical Academy n.a. I.I.Mechnikov of Ministry of Health, Saint Petersburg, Saint-Petersburg, Russian Federation
🇷🇺
City Tuberculosis Hospital #2 of Saint-Petersburg, Saint Petersburg, Saint-Petersburg, Russian Federation

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Modified RNA Vaccine Against Influenza

Phase 1

Completed

Conditions: Influenza, Human

Interventions: Biological: mIRV
Biological: bIRV AB
Biological: qIRV
Biological: QIV
Biological: bIRV AA
Biological: bIRV BB

First Posted Date: 2021-09-22

Last Posted Date: 2024-03-12

Lead Sponsor: Pfizer

Target Recruit Count: 1158

Registration Number: NCT05052697

Locations: 🇺🇸
NYU Langone Cardiology Associates, Delray Beach, Florida, United States
🇺🇸
Robert B. Pritt, DO, Fort Myers, Florida, United States
🇺🇸
Orange County Research Center, Tustin, California, United States

and more 89 locations

RNA Sequencing of Individual Versus Wastewater - SARS-CoV2

Completed

Conditions: Infection Viral

Interventions: Other: NO INTERVENTION

First Posted Date: 2021-09-13

Last Posted Date: 2021-09-13

Lead Sponsor: Centre Hospitalier Universitaire de Nice

Target Recruit Count: 1409

Registration Number: NCT05041764

Locations: 🇫🇷
Ipmc . Cnrs, Sophia Antipolis, France
🇫🇷
Nice Hospital, Nice, France

Contribution of Nasal IgE Production to the Boost of Systemic Allergen-specific IgE Upon Nasal Allergen Contact

Not Applicable

Recruiting

Conditions: Allergy

Interventions: Procedure: Blood sampling
Procedure: Nasal biopsies
Biological: Nasal specimen collection
Procedure: Mucosal RNA sampling
Procedure: Intranasal challenge
Procedure: Skin prick test
Procedure: Peak Nasal Inspiratory Flow (PNIF)
Biological: Pregnancy test

First Posted Date: 2021-09-13

Last Posted Date: 2025-05-07

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 30

Registration Number: NCT05042830

Locations: 🇦🇹
Medical University of Vienna, Vienna, Austria

A Trial Evaluating the Safety and Immunogenicity of 3 COVID-19 SARS-CoV-2 RNA Vaccines in Healthy Adults

Phase 1

Completed

Conditions: SARS-CoV-2 Infection
COVID-19
Corona Virus Infection

Interventions: Biological: ARCT-021
Biological: ARCT-154
Biological: ARCT-165

First Posted Date: 2021-09-08

Last Posted Date: 2024-12-18

Lead Sponsor: Arcturus Therapeutics, Inc.

Target Recruit Count: 72

Registration Number: NCT05037097

Locations: 🇸🇬
Arcturus Investigational Site 101, Singapore, Singapore
🇺🇸
Arcturus Investigational Site 202, Wichita, Kansas, United States
🇿🇦
Arcturus Investigational Site 301, Diepkloof, Soweto, South Africa

and more 1 locations

Extracellular RNA Biomarkers of Myotonic Dystrophy

Recruiting

Conditions: Myotonic Dystrophy

First Posted Date: 2021-08-25

Last Posted Date: 2023-10-06

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 215

Registration Number: NCT05020002

Locations: 🇺🇸
University of Texas Southwestern, Dallas, Texas, United States
🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Extracellular RNA Biomarkers of Duchenne Muscular Dystrophy

Recruiting

Conditions: Duchenne Muscular Dystrophy

First Posted Date: 2021-08-23

Last Posted Date: 2023-10-12

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 100

Registration Number: NCT05016908

Locations: 🇺🇸
Boston Children's Hospital, Boston, Massachusetts, United States
🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

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