Risperidone

Generic Name: Risperidone

Brand Names: Perseris, Risperdal, Rykindo, Uzedy, Okedi

Drug Type: Small Molecule

Chemical Formula: C_₂₃H_₂₇FN_₄O_₂

CAS Number: 106266-06-2

Unique Ingredient Identifier: L6UH7ZF8HC

Background: Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).
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Indication: Risperidone is indicated for the treatment of schizophrenia and irritability associated with autistic disorder. It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.
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Associated Conditions: Acute Mania, Irritability, Mixed manic depressive episode, Psychosis, Schizophrenia, Acute Manic episode, Agitated psychotic state

Associated Therapies: -

Clinical Trials

Different Safety Profile of Risperidone and Paliperidone Extended-release

Phase 4

Completed

Conditions: Schizophrenia

Interventions: Drug: paliperidone ER
Drug: placebo
Drug: risperidone

First Posted Date: 2011-01-27

Last Posted Date: 2012-10-23

Lead Sponsor: Chonbuk National University Hospital

Target Recruit Count: 34

Registration Number: NCT01284959

Locations: 🇰🇷
Chonbuk national university hospital, Chonju, Korea, Republic of

Risperidone vs. Olanzapine as add-on Treatment in Treatment Resistant Depression

Phase 1

Completed

Conditions: Subjects Had Unipolar, Non-psychotic Major Depression

Interventions: Drug: Risperidone
Drug: Olanzapine

First Posted Date: 2011-01-25

Last Posted Date: 2011-01-25

Lead Sponsor: Sunnybrook Health Sciences Centre

Target Recruit Count: 42

Registration Number: NCT01282632

Locations: 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Typical Versus Atypical Antipsychotics; Occupation of Striatal Receptors and the Appearance of Extrapyramidal Symptomatology, in Healthy Volunteers

Phase 1

Conditions: Pharmacogenetics
Healthy

Interventions: Drug: Risperidone
Drug: Placebo
Drug: Haloperidol

First Posted Date: 2010-12-15

Last Posted Date: 2011-04-18

Lead Sponsor: Hospital Clinic of Barcelona

Target Recruit Count: 24

Registration Number: NCT01259973

Locations: 🇪🇸
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
🇪🇸
Hospital Clinic of Barcelona, Barcelona, Spain

Atypical Antipsychotic Treatment Effect On Brain Function In Schizophrenia Measured By FMRI

Not Applicable

Completed

Conditions: Schizophrenia

Interventions: Drug: Olanzapine
Drug: Risperidone

First Posted Date: 2010-11-04

Last Posted Date: 2015-04-03

Lead Sponsor: University of North Carolina, Chapel Hill

Target Recruit Count: 34

Registration Number: NCT01234454

Locations: 🇺🇸
Unc Psychiatry, Chapel Hill, North Carolina, United States

Bioequivalence Study of Risperidone 1 mg Orally-disintegrating Tablets Under Fed Conditions

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Risperidone

First Posted Date: 2010-10-18

Last Posted Date: 2010-10-18

Lead Sponsor: Ranbaxy Laboratories Limited

Target Recruit Count: 40

Registration Number: NCT01222923

Locations: 🇺🇸
aaiPharma Inc., Chapel Hill, North Carolina, United States

Bioequivalence Study of Risperidone 1 mg Orally-disintegrating Tablets Under Fasting Conditions

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Risperidone

First Posted Date: 2010-10-18

Last Posted Date: 2010-10-18

Lead Sponsor: Ranbaxy Laboratories Limited

Target Recruit Count: 44

Registration Number: NCT01222975

Locations: 🇺🇸
aaiPharma Inc., Chapel Hill, North Carolina, United States

Twelve Month Study Comparing Paliperidone Palmitate and Select Oral Antipsychotics in Adults With Schizophrenia Who Have Been Recently Discharged From an Inpatient Psychiatric Hospital

Phase 4

Withdrawn

Conditions: Schizophrenia

Interventions: Drug: haloperidole
Drug: perphenazine
Drug: paliperidone palmitate
Drug: olanzapine
Drug: paliperidone
Drug: aripiprazole
Drug: risperidone
Drug: quetiapine

First Posted Date: 2010-09-01

Last Posted Date: 2013-07-08

Lead Sponsor: Ortho-McNeil Janssen Scientific Affairs, LLC

Registration Number: NCT01193166

Evaluation of Negative Symptoms and Cognitive Function After Administration of Antipsychotics in Healthy Volunteer

Completed

Conditions: Normal Volunteers

Interventions: Drug: risperidone
Drug: aripiprazole
Drug: haloperidol
Drug: amisulpride
Drug: lactose

First Posted Date: 2010-08-20

Last Posted Date: 2010-08-20

Lead Sponsor: Chonbuk National University Hospital

Target Recruit Count: 80

Registration Number: NCT01185418

Locations: 🇰🇷
Chonbuk national university hospital, Jeonju, Korea, Republic of

An Inpatient Study Of The Efficacy, Safety, And Tolerability Of PF-02545920 In The Treatment Of Acute Exacerbation Of Schizophrenia

Phase 2

Completed

Conditions: Schizophrenia

Interventions: Drug: Risperidone
Drug: PF-02545920
Drug: Placebo

First Posted Date: 2010-08-04

Last Posted Date: 2018-05-22

Lead Sponsor: Pfizer

Target Recruit Count: 259

Registration Number: NCT01175135

Locations: 🇩🇪
Zentralinstitut fuer Seelische Gesundheit, Mannheim, Germany
🇺🇦
Kyiv City Psychoneurological Hospital #2, Kyiv, Ukraine
🇺🇦
Kyiv City Clinical Psychoneurological Hospital #1, Kyiv, Ukraine

and more 40 locations

Risperidone Treatment In Children With Autism Spectrum Disorder And High Levels Of Repetitive Behavior

Phase 2

Completed

Conditions: Autism

Interventions: Drug: Risperidone
Drug: Placebo

First Posted Date: 2010-07-29

Last Posted Date: 2022-05-17

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 41

Registration Number: NCT01171937

Locations: 🇺🇸
UCLA, Los Angeles, California, United States

Drug Development Updates

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